上转换纳米材料在新兴光学生物应用中的最新进展。
Recent progress in upconversion nanomaterials for emerging optical biological applications.
机构信息
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
出版信息
Adv Drug Deliv Rev. 2022 Sep;188:114414. doi: 10.1016/j.addr.2022.114414. Epub 2022 Jul 6.
The recent advances of upconversion nanoparticles (UCNPs) have made them the ideal "partner" for a variety of biological applications. In this review, we describe the emerging biological optical applications of UCNPs, focus on their potential therapeutic advantages. Firstly, we briefly review the development and mechanisms of upconversion luminescence, including organic and inorganic UCNPs. Next, in the section on UCNPs for imaging and detection, we list the development of UCNPs in visualization, temperature sensing, and detection. In the section on therapy, recent results are described concerning optogenetics and neurotherapy. Tumor therapy is another major part of this section, including the synergistic application of phototherapy such as photoimmunotherapy. In a special section, we briefly cover the integration of UCNPs in therapeutics. Finally, we present our understanding of the limitations and prospects of applications of UCNPs in biological fields, hoping to provide a more comprehensive understanding of UCNPs and attract more attention.
上转换纳米粒子（UCNPs）的最新进展使它们成为各种生物应用的理想“伙伴”。在这篇综述中，我们描述了 UCNPs 在新兴生物光学应用中的发展，重点介绍了它们在治疗方面的潜在优势。首先，我们简要回顾了上转换发光的发展和机制，包括有机和无机 UCNPs。接下来，在 UCNPs 成像和检测部分，我们列出了 UCNPs 在可视化、温度感应和检测方面的发展。在治疗部分，我们描述了光遗传学和神经治疗方面的最新结果。肿瘤治疗是这部分的另一个主要内容，包括光疗如光免疫疗法的协同应用。在一个特别的部分，我们简要介绍了 UCNPs 在治疗中的整合。最后，我们提出了对 UCNPs 在生物领域应用的局限性和前景的理解，希望提供对 UCNPs 的更全面的理解，并吸引更多的关注。
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