Pinho Sandra, Miranda Isabel M, Costa-de-Oliveira Sofia
Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Cardiovascular R&D Centre UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
J Fungi (Basel). 2024 Aug 7;10(8):558. doi: 10.3390/jof10080558.
Emerging and uncommon species have been reported as an increasing cause of invasive infections (ICI). We aim to systematize the global epidemiology associated with emergent uncommon species responsible for invasive infections in adult patients. A systematic review (from 1 January 2001 to 28 February 2023) regarding epidemiological, clinical, and microbiological data associated to invasive infections by uncommon spp. were collected. In total, 1567 publications were identified, and 36 were selected according to inclusion criteria (45 cases). The chosen studies covered: ( = 21), ( = 6), ( = 4), ( = 4), ( = 3), ( = 3), ( = 1), ( = 1), ( = 1), and ( = 1). Over the recent years, there has been an increase in the number of invasive infections caused by uncommon spp. Asia and Europe are the continents with the most reported cases. The challenges in strain identification and antifungal susceptibility interpretation were significant. The absence of clinical breakpoints for the susceptibility profile determination for uncommon spp. makes interpretation and treatment options a clinical challenge. It is crucial that we focus on new and accessible microbiology techniques to make fast and accurate diagnostics and treatments.
新出现的和不常见的物种已被报道为侵袭性感染（ICI）日益增加的原因。我们旨在系统整理与导致成年患者侵袭性感染的新出现的不常见物种相关的全球流行病学情况。我们收集了一项系统评价（从2001年1月1日至2023年2月28日）中与不常见物种引起的侵袭性感染相关的流行病学、临床和微生物学数据。总共识别出1567篇出版物，并根据纳入标准选择了36篇（45例）。所选研究涵盖：（此处原文缺失具体物种名称）（ = 21），（ = 6），（ = 4），（ = 4），（ = 3），（ = 3），（ = 1），（ = 1），（ = 1），以及（ = 1）。近年来，由不常见物种引起的侵袭性感染数量有所增加。亚洲和欧洲是报告病例最多的大陆。菌株鉴定和抗真菌药敏结果解读方面存在重大挑战。缺乏针对不常见物种药敏谱测定的临床断点使得解读和治疗选择成为临床难题。我们专注于新的且可获得的微生物学技术以进行快速准确的诊断和治疗至关重要。
