de Almeida João N, Francisco Elaine C, Hagen Ferry, Brandão Igor B, Pereira Felicidade M, Presta Dias Pedro H, de Miranda Costa Magda M, de Souza Jordão Regiane T, de Groot Theun, Colombo Arnaldo L
Laboratório Especial de Micologia, Disciplina de Infectologia, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Divisão de Laboratório Central, Hospital das Clínicas da Universidade de São Paulo, São Paulo 01246-100, Brazil.
J Fungi (Basel). 2021 Mar 17;7(3):220. doi: 10.3390/jof7030220.
In December 2020, emerged in Brazil in the city of Salvador. The first two colonized patients were in the same COVID-19 intensive care unit. Antifungal susceptibility testing showed low minimal inhibitory concentrations of 1 µg/mL, 2 µg/mL, 0.03 µg/L, and 0.06 µg/mL for amphotericin B, fluconazole, voriconazole, and anidulafungin, respectively. Microsatellite typing revealed that the strains are clonal and belong to the South Asian clade . The travel restrictions during the COVID-19 pandemic and the absence of travel history among the colonized patients lead to the hypothesis that this species was introduced several months before the recognition of the first case and/or emerged locally in the coastline Salvador area.
2020年12月,在巴西萨尔瓦多市出现。最初两名定植患者在同一间新冠重症监护病房。抗真菌药敏试验显示,两性霉素B、氟康唑、伏立康唑和阿尼芬净的最低抑菌浓度分别低至1µg/mL、2µg/mL、0.03µg/L和0.06µg/mL。微卫星分型显示这些菌株是克隆性的,属于南亚分支。新冠疫情期间的旅行限制以及定植患者中无旅行史,这引发了一种假说,即该菌种在首例病例被识别前几个月就已传入和/或在萨尔瓦多沿海地区本地出现。