Jamali Farzaneh, Shahrami Bita, Mojtahedzadeh Amirmahdi, Najmeddin Farhad, Arabzadeh Amir Ahmad, Hadadi Azar, Sharifzadeh Mohammad, Mojtahedzadeh Mojtaba
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Semmelweis University, Faculty of Medicine, Budapest, Hungary.
J Lipids. 2022 Jul 5;2022:8527305. doi: 10.1155/2022/8527305. eCollection 2022.
This pilot study aimed to determine early changes of LXA levels among the hospitalized patients confirmed as COVID-19 cases following the clinical management and its correlation with commonly used inflammatory markers, including erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), and ferritin. Thirty-one adult hospitalized patients infected with the non-severe COVID-19 were included. LXA levels were measured at the baseline and 48-72 hours after hospitalization. Accordingly, ESR and CRP levels were collected on the first day of hospitalization. Moreover, the maximum serum ferritin levels were determined during the five days. LXA levels significantly increased at 48-72 hours compared to the baseline. ESR, CRP, and ferritin levels were positively correlated with the increased LXA4. In contrast, aging was shown to negatively correlate with the increased LXA levels. LXA may be known as a valuable marker to assess the treatment response among non-elderly patients with non-severe COVID-19. Furthermore, LXA could be considered as a potential treatment option under inflammatory conditions. Further studies are necessary to clarify LXA role in COVID-19 pathogenesis, as well as the balance between such pro-resolving mediators and inflammatory parameters.
这项初步研究旨在确定确诊为新冠肺炎病例的住院患者在临床治疗后LXA水平的早期变化及其与常用炎症标志物的相关性，这些标志物包括红细胞沉降率（ESR）、C反应蛋白（CRP）和铁蛋白。纳入了31名感染非重症新冠肺炎的成年住院患者。在基线期以及住院后48 - 72小时测量LXA水平。相应地，在住院第一天收集ESR和CRP水平。此外，在五天内测定血清铁蛋白的最高水平。与基线相比，LXA水平在48 - 72小时显著升高。ESR、CRP和铁蛋白水平与LXA4的升高呈正相关。相反，年龄与LXA水平的升高呈负相关。LXA可能是评估非重症新冠肺炎非老年患者治疗反应的一个有价值的标志物。此外，在炎症条件下，LXA可被视为一种潜在的治疗选择。有必要进一步研究以阐明LXA在新冠肺炎发病机制中的作用，以及这种促解决介质与炎症参数之间的平衡。
