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心内科冠心病急性冠脉综合征的临床特征及其与肿瘤坏死因子的相关性。

Clinical Features of Acute Coronary Syndrome in Patients with Coronary Heart Disease and Its Correlation with Tumour Necrosis Factor in Cardiology.

机构信息

Department of Cardiovascular Medicine, Cangzhou Central Hospital, Cangzhou, 061000 Hebei, China.

出版信息

Comput Math Methods Med. 2022 Jun 30;2022:3439768. doi: 10.1155/2022/3439768. eCollection 2022.

Abstract

Tumour necrosis factor (TNF) levels are higher in patients who have experienced an acute ischemic stroke. Greater levels of TNF may not be linked to an increased risk of recurrent coronary events in the stable phase after myocardial ischemia (MI). Coronary atheroma is connected to endothelial and smooth muscle cells, as well as macrophages that emit the multifunctional cytokine tumour necrosis factor (TNF). Transplanted tumours become more vulnerable when TNF- was first recognized to have a function in hemorrhagic necrosis. TNF- has been demonstrated to induce heart failure, pulmonary edoema, and cardiomyopathy in people with advanced heart failure when it is elevated in the bloodstream. It has been postulated that prolonged overexpression of TNF- after ischemia may contribute to poor cardiac outcomes by increasing TNF- when the myocardium undergoes both temporary ischemia and reperfusion. A rise in TNF levels has been seen after a myocardial infarction, but it is unclear if these higher levels, found months after the initial event, are associated with an increased risk of subsequent heart attacks. We looked at TNF levels in the blood of 270 patients with coronary heart disease in the Chinese Hypertension League's Cholesterol and Recurrent Events (CARE) experiment to see if this notion held true. Recurrent coronary syndrome and coronary mortality were monitored prospectively in the participants. The min max imbalance normalization can be used to assess a patient's baseline characteristics, including hormone and cholesterol test results. Type 2 stimulant connection to aggregate the TNF-signaling qualities and fuzzy techniques was applied. There may now be enough preliminary evidence from the crucial bundle neural network analysis to identify the risk of coronary heart disease associated with TNF pregeneration studies. The tests were assessed using a variety of methods and performance metrics in a Matlab environment.

摘要

肿瘤坏死因子 (TNF) 水平在经历急性缺血性中风的患者中较高。在心肌缺血 (MI) 后的稳定期,较高水平的 TNF 可能与复发性冠状动脉事件的风险增加无关。冠状动脉粥样硬化与内皮和平滑肌细胞以及巨噬细胞有关,巨噬细胞会释放多功能细胞因子肿瘤坏死因子 (TNF)。当 TNF- 首次被发现具有促进出血性坏死的功能时,移植的肿瘤变得更加脆弱。当 TNF- 在血液中升高时,它已被证明会导致心力衰竭、肺水肿和心肌病,尤其是在患有晚期心力衰竭的人群中。有人推测,缺血后 TNF- 的过度表达时间延长可能会通过在心肌经历短暂缺血和再灌注时增加 TNF- 而导致不良心脏结局。心肌梗死后 TNF 水平升高,但尚不清楚最初事件发生数月后发现的这些更高水平是否与随后发生心脏病发作的风险增加有关。我们观察了中国高血压联盟胆固醇和复发性事件 (CARE) 实验中 270 名冠心病患者的血液 TNF 水平,以确定这一观点是否成立。前瞻性监测参与者的复发性冠状动脉综合征和冠状动脉死亡率。最小最大不平衡归一化可用于评估患者的基线特征,包括激素和胆固醇测试结果。采用 2 型刺激物连接聚合 TNF 信号特性和模糊技术。现在,从关键的束状神经网络分析中可能已经有足够的初步证据来识别与 TNF 前体研究相关的冠心病风险。在 Matlab 环境中使用各种方法和性能指标评估了这些测试。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5069/9262531/7ce8ff36c5ce/CMMM2022-3439768.001.jpg

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