Girotti M J, Hong K, Demajo W C, Todd T R
Can J Anaesth. 1987 May;34(3 ( Pt 1)):252-8. doi: 10.1007/BF03015162.
We compared the effects of high frequency jet ventilation (HFV), conventional ventilation (CMV), and spontaneous breathing (SB) on regional pulmonary blood flows (QLLL), standard cardiopulmonary measurements and the serum levels of the first generation metabolites of prostacyclin (6-keto-PGF1 alpha) and thromboxane A2 (TxB2) in established left lower lobe pseudomonas aeruginosa pneumonia in 11 sheep. Gram negative pneumonia resulted in significant increases in alveolar-arterial oxygen gradients [(A-a)DO2] and pulmonary shunt fractions (Qs/Qt), as well as a significant decrease in QLLL during SB. Significant differences in standard haemodynamics, (A-a)DO2, Qs/Qt, and QLLL were not observed when HFV was compared to CMV. However, serum levels of 6-keto-PGF1 alpha were elevated when the animals underwent HFV. We conclude that HFV is a safe and efficient method of oxygenation and ventilation in unilobar gram negative pneumonia and also results in a significant increase in the serum levels of 6-keto-PGF1 alpha when compared to CMV in sheep. The exact significance of the latter finding is the subject of current investigation.
我们比较了高频喷射通气（HFV）、传统通气（CMV）和自主呼吸（SB）对11只绵羊左下叶铜绿假单胞菌肺炎模型中局部肺血流（QLLL）、标准心肺测量指标以及前列环素第一代代谢产物（6-酮-前列腺素F1α）和血栓素A2（TxB2）血清水平的影响。革兰阴性菌肺炎导致自主呼吸时肺泡-动脉氧梯度[（A-a）DO2]和肺分流分数（Qs/Qt）显著增加，同时QLLL显著降低。将高频喷射通气与传统通气相比较时，未观察到标准血流动力学、（A-a）DO2、Qs/Qt和QLLL存在显著差异。然而，动物接受高频喷射通气时，血清6-酮-前列腺素F1α水平升高。我们得出结论，在单叶革兰阴性菌肺炎中，高频喷射通气是一种安全有效的氧合和通气方法，与传统通气相比，还会使绵羊血清6-酮-前列腺素F1α水平显著升高。后一发现的确切意义是当前研究的主题。
