Schuster D P, Snyder J V, Klain M
Anesth Analg. 1982 Sep;61(9):735-40.
High-frequency jet ventilation (HFJV) was compared with conventional ventilation ventilation during oleic acid-induced pulmonary edema in dogs. HFJV, when combined with positive end-expiratory pressure (PEEP), returned arterial PO2 (PAO2) and venous admixture to preoleic acid levels, even with tidal volumes as low as 4.8 ml/kg and rates of 300 min-1. When HFJV was compared with conventional (low-frequency, high tidal volume) ventilation at the same Flo2 and level of PEEP, Pao2 was lower and venous admixture higher with HFJV. However, venous admixture was lower with HFJV when comparisons were made at the same peak airway pressure, because of a higher level of PEEP compared with conventional ventilation. At each level of PEEP, cardiac and stroke indices were not different between the two methods of ventilation. The ability to eliminate CO2 with lower peak airway pressures or to increase PEEP without further increases in peak airway pressure are the primary advantages of HFJV during severe lung injury. Oxygenation is as efficient during HFJV as during conventional ventilation in this model of pulmonary edema when comparisons are made at the same peak airway pressure, but less efficient at the same PEEP.
在油酸诱导的犬肺水肿模型中，对高频喷射通气（HFJV）与传统通气进行了比较。HFJV联合呼气末正压（PEEP）时，即使潮气量低至4.8 ml/kg、频率为300次/分钟，动脉血氧分压（PAO2）和静脉血掺杂也能恢复到油酸注入前的水平。当在相同的吸入氧分数（Flo2）和PEEP水平下，将HFJV与传统（低频、大潮气量）通气进行比较时，HFJV组的Pao2较低，静脉血掺杂较高。然而，当在相同的气道峰压下进行比较时，HFJV组的静脉血掺杂较低，这是因为与传统通气相比，其PEEP水平较高。在每个PEEP水平上，两种通气方法的心脏指数和每搏量指数并无差异。在严重肺损伤期间，HFJV的主要优势在于能够以较低的气道峰压排出二氧化碳，或者在不进一步增加气道峰压的情况下增加PEEP。在该肺水肿模型中，当在相同的气道峰压下进行比较时，HFJV期间氧合与传统通气期间一样有效，但在相同的PEEP下效率较低。
