Herbaczynska-Cedro K, Truskolaski P, Huszczuk A, Dusting G J
Prostaglandins. 1981 May;21(5):707-17. doi: 10.1016/0090-6980(81)90228-8.
A prostacyclin-like substance was detected by bioassay in the blood of dogs and cats during hypoventilation and increased end-expiratory pressure. This biologically active material, most likely originating from lungs, relaxed isolated vascular strips and disaggregated platelets. Its release was not prevented by indomethacin or aspirin. Biological activity was not abolished by 10 min incubation of blood at 38 degrees C. Although the identity of the substance has not been established the release of a biologically active prostacyclin-like material might play a role in circulatory adaptation to disturbed ventilatory function.
在犬和猫通气不足及呼气末压力增加时，通过生物测定法在其血液中检测到一种类前列环素物质。这种生物活性物质很可能源自肺，可使离体血管条舒张并使血小板解聚。吲哚美辛或阿司匹林不能阻止其释放。血液在38℃孵育10分钟后生物活性并未消除。尽管该物质的身份尚未确定，但一种具有生物活性的类前列环素物质的释放可能在对通气功能紊乱的循环适应中起作用。
