Estrella R, Hercberg S, Maggy G, Larreategui J, Yepez R
Clin Chim Acta. 1987 Apr 15;164(1):1-6. doi: 10.1016/0009-8981(87)90100-8.
Hemoglobin, hematocrit, serum iron and total iron-binding capacity were measured in 38 apparently healthy children living in Quito (2:800 meters in altitude). One child was considered anemic according to the WHO reference adjusted to altitude (hemoglobin less than 12.3 g/dl) and 10 had transferrin saturation of less than 15%. Thirty children received orally 2 mg/kg per day of elemental iron for 3 mth. A significant increase in hemoglobin level, serum iron-concentration, and transferrin saturation, and a significant decrease in total iron-binding capacity were observed. Nine children increased their hemoglobin concentration by greater than 1 g/100 ml and could be considered as true anemics. At the end of the supplementation, only one child had a transferrin saturation coefficient of less than 15%. WHO references for hemoglobin adjusted to altitude seem to underestimate the prevalence of anemia for populations living at high altitudes.
对居住在基多（海拔2800米）的38名看似健康的儿童进行了血红蛋白、血细胞比容、血清铁和总铁结合力的测量。根据调整至该海拔高度的世界卫生组织参考标准，有1名儿童被认为贫血（血红蛋白低于12.3 g/dl），10名儿童的转铁蛋白饱和度低于15%。30名儿童每天口服2 mg/kg元素铁，持续3个月。观察到血红蛋白水平、血清铁浓度和转铁蛋白饱和度显著增加，总铁结合力显著降低。9名儿童的血红蛋白浓度升高超过1 g/100 ml，可被视为真正的贫血患者。补充结束时，只有1名儿童的转铁蛋白饱和系数低于15%。针对海拔高度调整后的世界卫生组织血红蛋白参考标准似乎低估了高海拔地区人群的贫血患病率。
