Gong Ya Qi, Wei Shuang, Wei Yuan Yun, Chen Yong Lin, Cui Jian, Yu Yue Qiu, Lin Xiang, Yan Hong Xia, Qin Hui, Yi Lan
Institute of Cytology and Genetics, The Hengyang Key Laboratory of Cellular Stress Biology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.
Institute of Cardiovascular Disease, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.
Oncol Lett. 2022 Jun 24;24(2):278. doi: 10.3892/ol.2022.13398. eCollection 2022 Aug.
As the risk of harmful environmental exposure is increasing, it is important to find suitable targets for the diagnosis and treatment of the diseases caused. Isocitrate dehydrogenase 2 (IDH2) is an enzyme located in the mitochondria; it plays an important role in numerous cell processes, including maintaining redox homeostasis, participating in the tricarboxylic acid cycle and indirectly taking part in the transmission of the oxidative respiratory chain. IDH2 mutations promote progression in acute myeloid leukemia, glioma and other diseases. The present review mainly summarizes the role and mechanism of IDH2 with regard to the biological effects, such as the mitophagy and apoptosis of animal or human cells, caused by environmental pollution such as radiation, heavy metals and other environmental exposure factors. The possible mechanisms of these biological effects are described in terms of IDH2 expression, reduced nicotine adenine dinucleotide phosphate content and reactive oxygen species level, among other variables. The impact of environmental pollution on human health is increasingly attracting attention. IDH2 may therefore become useful as a potential diagnostic and therapeutic target for environmental exposure-induced diseases.
随着有害环境暴露风险的增加，找到由其引发疾病的合适诊断和治疗靶点至关重要。异柠檬酸脱氢酶2（IDH2）是一种位于线粒体中的酶；它在众多细胞过程中发挥重要作用，包括维持氧化还原稳态、参与三羧酸循环以及间接参与氧化呼吸链的传递。IDH2突变会促进急性髓系白血病、胶质瘤等疾病的进展。本综述主要总结了IDH2在辐射、重金属等环境污染及其他环境暴露因素所导致的动物或人类细胞的生物学效应（如线粒体自噬和凋亡）方面的作用及机制。这些生物学效应的可能机制从IDH2表达、还原型烟酰胺腺嘌呤二核苷酸磷酸含量降低和活性氧水平等变量方面进行了描述。环境污染对人类健康的影响日益受到关注。因此，IDH2可能成为环境暴露所致疾病潜在的诊断和治疗靶点。
