Liang Jiaquan, Cai Yanshan, Xue Xiongyan, Li Xiaoling, Li Zaifang, Xu Caixia, Xie Guojun, Yu Yang
Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, China.
Front Psychiatry. 2022 Jun 23;13:934384. doi: 10.3389/fpsyt.2022.934384. eCollection 2022.
Schizophrenia (SC) is considered the most serious of all mental disorders. Some antipsychotics are associated with weight gain and metabolic abnormalities. Whether SC itself causes obesity remains uncertain.
We collected 185 first-episode drug-naive SC and 59 healthy controls (HCs) from the Third People's Hospital of Foshan, Guangdong, China, and distinguished their course of disease in order to understand the body mass index (BMI) and body fat metabolism of SC.
We found that excluding the drug factors, the longer the course of SC, the more obvious the increase of BMI and the higher the proportion of obesity. BMI was positively correlated with age, course of disease, fasting blood glucose (FBG), low-density lipoprotein (LDL), triglyceride (TG), and total cholesterol (TC), and negatively correlated with high-density lipoprotein (HDL). The results of regression analysis were further proof that age ( = 0.094, < 0.001), duration (B = 0.081, = 0.002), FBG ( = 0.987, = 0.004), and TG ( = 0.918, = 0.002) were the risk factors for the increase of BMI. HDL (B = -2.875, < 0.001) was the protective factor.
SC itself can increase BMI and easily lead to obesity. We should pay more attention to the monitoring of blood metabolism indicators, so as to reduce the risk of obesity and improve the quality of life of patients.
精神分裂症被认为是所有精神障碍中最严重的一种。一些抗精神病药物与体重增加和代谢异常有关。精神分裂症本身是否会导致肥胖仍不确定。
我们从中国广东佛山第三人民医院收集了185例首发未用药的精神分裂症患者和59名健康对照者，并区分他们的病程，以了解精神分裂症患者的体重指数（BMI）和体脂代谢情况。
我们发现，排除药物因素后，精神分裂症病程越长，BMI升高越明显，肥胖比例越高。BMI与年龄、病程、空腹血糖（FBG）、低密度脂蛋白（LDL）、甘油三酯（TG）和总胆固醇（TC）呈正相关，与高密度脂蛋白（HDL）呈负相关。回归分析结果进一步证明，年龄（β = 0.094，P < 0.001）、病程（β = 0.081，P = 0.002）、FBG（β = 0.987，P = 0.004）和TG（β = 0.918，P = 0.002）是BMI升高的危险因素。HDL（β = -2.875，P < 0.001）是保护因素。
精神分裂症本身可增加BMI并易导致肥胖。我们应更加关注血液代谢指标的监测，以降低肥胖风险，提高患者生活质量。
