Fei Dong-Qing, Li Hui-Hong, Chen Xiao-Han, Cui Wen-Bo, Zhang Zong-Ping, Zhan Xiao-Qing, Wang Mei-Jie, Qi Feng-Ming, Zhang Zhan-Xin, Li Er-Wei
School of Pharmacy, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, China.
Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Front Chem. 2022 Jun 24;10:911543. doi: 10.3389/fchem.2022.911543. eCollection 2022.
One novel diterpenoid lactone named caesalpinbondin A () that possesses an unprecedented tetracyclic ring system in which a 6/6/5-fused tricyclic ring and a 4,5-dimethyldihydrofuran-2(3H)-one were connected by a C-C single bond comprising a 5-(naphtho [2,3-b]furan-7-yl)dihydrofuran-2(3H)-one moiety was isolated from the seeds of . Its chemical structure was established by extensive spectroscopic methods, and its absolute configuration was further determined by single-crystal X-ray diffraction analysis and electronic circular dichroism calculation. The biological evaluation suggested that compound demonstrated potent anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD . A possible biogenetic pathway of was also proposed.
从[植物名称]种子中分离出一种名为决明内酯A（）的新型二萜内酯，它具有前所未有的四环环系，其中一个6/6/5稠合三环和一个4,5-二甲基二氢呋喃-2(3H)-酮通过一个碳-碳单键相连，该单键包含一个5-(萘并[2,3-b]呋喃-7-基)二氢呋喃-2(3H)-酮部分。通过广泛的光谱方法确定了其化学结构，并通过单晶X射线衍射分析和电子圆二色性计算进一步确定了其绝对构型。生物学评价表明，该化合物表现出强大的抗阿尔茨海默病（AD）生物活性，可延缓转基因AD小鼠的瘫痪。还提出了该化合物可能的生源合成途径。
