School of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Org Biomol Chem. 2019 Dec 18;18(1):76-80. doi: 10.1039/c9ob02334h.
Eupulcherol A (1), a novel triterpenoid with an unprecedented carbon skeleton, was isolated from Euphorbia pulcherrima. Its structure was determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR, and the absolute configuration was defined by single crystal X-ray diffraction analysis. Biological studies showed that compound 1 possessed anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD Caenorhabditis elegans. A plausible biogenetic pathway for eupulcherol A (1) was also proposed.
美丽泽兰醇 A（1）是一种新型三萜类化合物，具有前所未有的碳骨架，从美丽泽兰中分离得到。其结构通过包括 HRESIMS 在内的光谱数据的综合分析以及 1D 和 2D NMR 确定，绝对构型通过单晶 X 射线衍射分析确定。生物研究表明，化合物 1 具有抗阿尔茨海默病（AD）的生物活性，可延缓转基因 AD 秀丽隐杆线虫的瘫痪。还提出了美丽泽兰醇 A（1）的可能生物合成途径。
