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基于网络药理学和实验研究探讨半夏泻心汤治疗结肠癌的分子机制

Investigation of Molecular Mechanism of Banxia Xiexin Decoction in Colon Cancer via Network Pharmacology and Studies.

作者信息

Ma Lili, Fang Xiaojie, Yin Xin, Li Yanyan

机构信息

College Infirmary, Zhejiang Technical Institute of Economics, Hangzhou 310018, China.

Department of Anorectal Surgery, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China.

出版信息

Evid Based Complement Alternat Med. 2022 Jul 1;2022:4961407. doi: 10.1155/2022/4961407. eCollection 2022.

DOI:10.1155/2022/4961407
PMID:35815259
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9270134/
Abstract

OBJECTIVE

Banxia Xiexin decoction (BXD) is widely used in the treatment of gastrointestinal and other digestive diseases. This study is based on network pharmacology to explore the molecular mechanism of BXD in the treatment of colon cancer.

METHODS

The bioactive components and potential targets of BXD were obtained from public database. The protein-protein interaction (PPI) network of the potential targets of BXD for colon cancer was constructed based on the STRING database, cytoscape software, gene ontology (GO), and kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis of the PPI network. Finally, we established a xenograft nude mouse model to verify the effect of BXD in colon cancer treatment.

RESULTS

We have acquired a total of 55 bioactive components and 136 cross-targets of BXD. The results of enrichment analysis suggested that the oxidate stress and diet were the key factors of colon cancer occurrence, and AGE-RAGE signaling pathway plays an essential role in the treatment of colon cancer with BXD. Animal experiments revealed that BXD could suppress tumor growth and induce tumor cell apoptosis in the xenograft nude mouse model with HCT116 cells.

CONCLUSION

This study uncovered that BXD inhibits the malignant progression of colon cancer that may be related to multiple compounds (berberine, quercetin, baicalein, etc.), multiple targets (Bcl2, Bax, IL6, TNF, CASP3, etc.), and multiple pathways (human cytomegalovirus infection, AGE-RAGE signaling pathway in diabetic complications, etc.).

摘要

目的

半夏泻心汤广泛应用于胃肠道及其他消化系统疾病的治疗。本研究基于网络药理学探讨半夏泻心汤治疗结肠癌的分子机制。

方法

从公共数据库中获取半夏泻心汤的生物活性成分和潜在靶点。基于STRING数据库、Cytoscape软件构建半夏泻心汤治疗结肠癌潜在靶点的蛋白质-蛋白质相互作用（PPI）网络，并对该PPI网络进行基因本体论（GO）和京都基因与基因组百科全书（KEGG）通路富集分析。最后，建立异种移植裸鼠模型以验证半夏泻心汤在结肠癌治疗中的作用。

结果

共获得半夏泻心汤55种生物活性成分和136个交叉靶点。富集分析结果表明，氧化应激和饮食是结肠癌发生的关键因素，晚期糖基化终产物受体（AGE-RAGE）信号通路在半夏泻心汤治疗结肠癌中起重要作用。动物实验显示，半夏泻心汤可抑制HCT116细胞异种移植裸鼠模型中的肿瘤生长并诱导肿瘤细胞凋亡。

结论

本研究揭示半夏泻心汤抑制结肠癌的恶性进展可能与多种化合物（黄连素、槲皮素、黄芩素等）、多个靶点（Bcl2、Bax、IL6、TNF、CASP3等）及多条通路（人巨细胞病毒感染、糖尿病并发症中的AGE-RAGE信号通路等）有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84b6/9270134/6e5f09fba3e2/ECAM2022-4961407.010.jpg
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