Department of General Surgery, Faculty of Cerrahpasa Medicine, Istanbul University-Cerrahpasa.
Department of Biochemistry, Yildiz Technical University.
Medicine (Baltimore). 2021 Mar 19;100(11):e25104. doi: 10.1097/MD.0000000000025104.
Our aim in this study was to investigate the relationship between serum ischemia modified albumin (IMA) levels with oxidative stress parameters [protein carbonyl (PCO), advanced protein oxidation products (AOPPs), malondialdehyde (MDA), total nitric oxide (NOx), prooxidant-antioxidant balance (PAB), and ferric reducing of antioxidant power (FRAP)] in breast cancer (BC) and colon cancer (CC).In total, 90 patients undergoing surgical treatment for BC (n = 45) or CC (n = 45) and 35 healthy controls were included in this cross-sectional study.The serum PCO, AOPPs, MDA, NOx, PAB, and IMA levels were all statistically significantly higher in the cancer patients than in the control group. MDA, NOx, and PAB levels were significantly lower in the BC group than in the CC group. FRAP values were statistically significantly lower in both the CC group and the BC group compared to the control. IMA showed a weak positive correlation with CA-19.9 (r = 0.423 P = .007) but a moderate positive correlation with tumor size in the CC group. IMA showed a positive correlation with metastasis, grade, and HER2 and a negative correlation with ER and PR in the BC group.Oxidative stress is a key player in the development of solid malignancies. Cancer development is a multistage process, and oxidative stress caused by the production of ROS/RNS in the breast and colon may predispose individuals to BC and CC. Patients with BC and CC had an impaired oxidative/antioxidant condition that favored oxidative stress. The ROC analysis indicated that IMA sensitivity above 80% could be used as a secondary biomarker in diagnosis.
本研究旨在探讨乳腺癌（BC）和结肠癌（CC）患者血清缺血修饰白蛋白（IMA）水平与氧化应激参数[蛋白羰基（PCO）、晚期蛋白氧化产物（AOPPs）、丙二醛（MDA）、总一氧化氮（NOx）、促氧化剂-抗氧化剂平衡（PAB）和铁还原抗氧化能力（FRAP）]之间的关系。本横断面研究共纳入 90 例接受手术治疗的 BC（n = 45）或 CC（n = 45）患者和 35 名健康对照者。与对照组相比，癌症患者的血清 PCO、AOPPs、MDA、NOx、PAB 和 IMA 水平均显著升高。BC 组的 MDA、NOx 和 PAB 水平显著低于 CC 组。与对照组相比，CC 组和 BC 组的 FRAP 值均显著降低。IMA 与 CA-19.9 呈弱正相关（r = 0.423，P = .007），但与 CC 组肿瘤大小呈中度正相关。在 BC 组中，IMA 与转移、分级、HER2 呈正相关，与 ER 和 PR 呈负相关。氧化应激是实体恶性肿瘤发展的关键因素。癌症的发展是一个多阶段的过程，而在乳房和结肠中产生的 ROS/RNS 引起的氧化应激可能使个体易患 BC 和 CC。BC 和 CC 患者的氧化/抗氧化状态受损，有利于氧化应激。ROC 分析表明，IMA 敏感性超过 80%可作为辅助诊断的二级生物标志物。
