School of Biological Sciences, Seoul National University, Seoul, South Korea.
Genes Brain Behav. 2022 Sep;21(7):e12826. doi: 10.1111/gbb.12826. Epub 2022 Jul 11.
The hippocampus is one of the most widely investigated brain regions with its massive contributions to multiple behaviours. Especially, the hippocampus is subdivided into the dorsal and ventral parts playing distinct roles. In this review, we will focus on the ventral hippocampus, especially the ventral CA1 (vCA1), whose role is being actively discovered. vCA1 is well known to be associated with emotion-like behaviour, in both positive (reward) and negative (aversive) stimuli. How can this small region in volume mediate such variety of responses? This question will be answered with technologies up to date that have allowed us to study in-depth the specific neural circuit and to map the complex connectivity.
海马体是研究最广泛的脑区之一,它对多种行为都有巨大的贡献。特别是,海马体被细分为发挥不同作用的背侧部和腹侧部。在这篇综述中,我们将重点关注腹侧海马体,特别是腹侧 CA1 区(vCA1),其作用正在被积极发现。vCA1 区与情绪样行为密切相关,包括正性(奖赏)和负性(厌恶)刺激。这个体积较小的区域如何能介导如此多样的反应?这个问题将通过最新的技术来回答,这些技术使我们能够深入研究特定的神经回路,并绘制出复杂的连接。