Department of Epidemiology. School of Public Health and Management. Research Center for Medicine and Social Development. Innovation Center for Social Risk Governance in Health. Chongqing Medical University.
Chongqing Medical University.
Nutr Hosp. 2022 Aug 25;39(4):778-785. doi: 10.20960/nh.04081.
Introduction: hypertension and diabetes are chronic disorders associated with an increased risk of cardiovascular disease. Objectives: to evaluate the effect of 52 % low-sodium salt applied to the Chinese-modified DASH (CM-DASH) diet on risk of atherosclerotic cardiovascular disease (ASCVD) in patients with hypertension and type-2 diabetes. Methods: the low-sodium salt group (LSSG) took 5 g/day of 52 % low-sodium salt plus CM-DASH diet for 8 weeks, while the normal-sodium salt group (NSSG) took the same dose of normal-sodium salt plus CM-DASH diet for 8 weeks. Blood tests, 24-hour urine tests, anthropometric measurements, and 10-year risk of ASCVD prediction were assessed. Results: compared with baseline, both LSSG and NSSG showed a significant reduction in 10-year risk of ASCVD, but we did not find any statistically significant differences in 10-year risk of ASCVD between LSSG and NSSG. Conclusions: our study shows that salt limits and DASH diets reduce the risk of cardiovascular disease whereas low-sodium salt containing 52 % sodium chloride did not significantly lower the risk of cardiovascular disease when compared to regular salt. Due to the limitations of the research, additional studies will be necessary to confirm our findings.
高血压和糖尿病是与心血管疾病风险增加相关的慢性疾病。目的：评估应用于中国改良 DASH（CM-DASH）饮食的 52%低钠盐对高血压合并 2 型糖尿病患者发生动脉粥样硬化性心血管疾病（ASCVD）的风险的影响。方法：低钠盐组（LSSG）每天服用 5 克 52%低钠盐加 CM-DASH 饮食 8 周，而正常钠盐组（NSSG）每天服用相同剂量的正常钠盐加 CM-DASH 饮食 8 周。检测血样、24 小时尿液样本、人体测量数据以及 ASCVD 10 年风险预测。结果：与基线相比，LSSG 和 NSSG 组的 ASCVD10 年风险均显著降低，但 LSSG 和 NSSG 组之间 ASCVD10 年风险无统计学差异。结论：本研究表明，盐限制和 DASH 饮食可降低心血管疾病风险，而与普通盐相比，含 52%氯化钠的低钠盐并不能显著降低心血管疾病风险。由于研究的局限性，还需要开展更多的研究来证实我们的发现。
