Okuma M, Yamori Y, Ohta K, Uchino H
Prostaglandins. 1979 Jan;17(1):1-7. doi: 10.1016/0090-6980(79)90070-4.
Activities of aortae to produce prostaglandin (PG) I2-like substance in stroke-prone spontaneously hypertensive rats (SHRSP), stroke-resistant SHR (SHRSR) and normotensive control rats from the Wistar-Kyoto (WK) colony were compared. PGI2-like substance was produced by the incubation of the aortic ring in pH 9.0 borate-buffered saline and the amount produced was estimated by comparison of its anti-aggregatory activity with that produced by known amounts of the sodium salt of synthetic PGI2. Before the development of stroke, amounts of this substance generated in SHRSP and SHRSR were significantly higher than those in WK rats (p less than 0.01 and p less than 0.02, respectively). Remarkably reduced capacity to generate PGI2-like substance was observed in some SHRSP after the development of stroke.
比较了易患中风的自发性高血压大鼠（SHRSP）、抗中风的自发性高血压大鼠（SHRSR）以及来自Wistar-Kyoto（WK）群体的正常血压对照大鼠的主动脉产生前列腺素（PG）I2样物质的活性。通过在pH 9.0硼酸盐缓冲盐水中孵育主动脉环来产生PGI2样物质，并通过将其抗聚集活性与已知量的合成PGI2钠盐产生的抗聚集活性进行比较来估计产生的量。在中风发生前，SHRSP和SHRSR中产生的这种物质的量显著高于WK大鼠（分别为p<0.01和p<0.02）。在中风发生后，在一些SHRSP中观察到产生PGI2样物质的能力显著降低。
