Bailey-Wood R, Clark R E, Dallimore C M, Jacobs A
Clin Lab Haematol. 1987;9(1):23-6. doi: 10.1111/j.1365-2257.1987.tb01378.x.
CFU-GM clonal growth was examined in bone marrow from patients with myelodysplastic syndrome (MDS) in the presence of Ara-C at 10(-8) M and 4 X 10(-8) M and the response compared to the effect on progenitors from normal subjects. Seventy-three percent of marrow cultures from patients with MDS showed colony growth below the 95% confidence limits for normal subjects in the presence of 10(-8) M Ara-C. At 4 X 10(-8) M Ara-C 43% of marrow cultures had subnormal colony growth. These results suggest that CFU-GM from patients with MDS may have a greater than normal sensitivity to Ara-C.
在10^(-8)M和4×10^(-8)M阿糖胞苷（Ara-C）存在的情况下，检测骨髓增生异常综合征（MDS）患者骨髓中的粒-巨噬细胞集落形成单位（CFU-GM）克隆生长，并将其反应与对正常受试者祖细胞的影响进行比较。在10^(-8)M阿糖胞苷存在的情况下，73%的MDS患者骨髓培养物显示集落生长低于正常受试者的95%置信限。在4×10^(-8)M阿糖胞苷时，43%的骨髓培养物集落生长低于正常水平。这些结果表明，MDS患者的CFU-GM对阿糖胞苷的敏感性可能高于正常水平。
