Fyad A, Masmoudi M L, Lachapelle J M
Contact Dermatitis. 1987 Mar;16(3):147-51. doi: 10.1111/j.1600-0536.1987.tb01409.x.
A positive "edge effect", i.e., the accumulation on the skin of a chemical solution (such as fluorescein 0.01% in a 50/50 water-ethanol solution) at the periphery of the patch test sites has been demonstrated. It occurs with different test materials (Finn Chamber; Silver Patch Test; Patch Test Chamber). Practical implications are discussed: this observation could be important when discussing results of laboratory investigations. In clinical practice, it could explain the occurrence of "ring-shaped" positive allergic patch test reactions to chemicals used in solution, i.e., Kathon CG or hydrocortisone.
已经证实存在一种阳性“边缘效应”，即化学溶液（如50/50水 - 乙醇溶液中的0.01%荧光素）在斑贴试验部位周边的皮肤累积现象。不同的试验材料（芬兰小室；银斑贴试验；斑贴试验小室）都会出现这种情况。文中讨论了实际影响：在讨论实验室研究结果时，这一观察结果可能很重要。在临床实践中，它可以解释对溶液中使用的化学物质（如凯松CG或氢化可的松）出现的“环状”阳性过敏性斑贴试验反应的发生原因。
