Gaebler Christian, DaSilva Justin, Bednarski Eva, Muecksch Frauke, Schmidt Fabian, Weisblum Yiska, Millard Katrina G, Turroja Martina, Cho Alice, Wang Zijun, Caskey Marina, Nussenzweig Michel C, Bieniasz Paul D, Hatziioannou Theodora
Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, USA.
Laboratory of Retrovirology, The Rockefeller University, New York, New York, USA.
Open Forum Infect Dis. 2022 May 7;9(7):ofac227. doi: 10.1093/ofid/ofac227. eCollection 2022 Jul.
The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infection increases neutralizing antibody titers to varying degrees depending on the nature of the breakthrough variant and the number of vaccine doses previously administered. Omicron breakthrough infection resulted in neutralizing antibody titers that were the highest across all groups, particularly against Omicron.
传染性更强且对中和抗体具有抗性的严重急性呼吸综合征冠状病毒2变体的出现，增加了突破性感染的发生率。我们发现，根据突破性变体的性质和先前接种的疫苗剂量，突破性感染会不同程度地提高中和抗体滴度。奥密克戎突破性感染导致的中和抗体滴度在所有组中是最高的，尤其是针对奥密克戎的中和抗体滴度。
