威尔逊病的高场磁共振成像

High-field magnetic resonance imaging of Wilson's disease.

作者信息

De Haan J, Grossman R I, Civitello L, Hackney D B, Goldberg H I, Bilaniuk L T, Zimmerman R A

出版信息

J Comput Tomogr. 1987 Apr;11(2):132-5. doi: 10.1016/0149-936x(87)90004-x.

Abstract

A single case of Wilson's hepatolenticular degeneration was imaged by computed tomography and magnetic resonance (1.5 Tesla). Findings included generalized cerebral atrophy seen both on computed tomography and magnetic resonance images. T1-weighted images revealed a slight symmetric hypointensity in the lentiform nuclei and thalamus. T2-weighted images demonstrated marked symmetric hypointensity in the lentiform nuclei. These hypointensities are ascribed to the deposition of intracellular hemosiderin (and perhaps copper), which produce heterogeneous magnetic susceptibility and preferential T2-proton relaxation. Areas of increased signal activity on T2-weighted images were also seen in areas of presumed demyelination known to occur in Wilson's disease.

摘要

对一例威尔逊肝豆状核变性患者进行了计算机断层扫描和磁共振成像（1.5特斯拉）。结果显示，计算机断层扫描和磁共振图像上均可见广泛性脑萎缩。T1加权图像显示豆状核和丘脑有轻微对称性低信号。T2加权图像显示豆状核有明显对称性低信号。这些低信号归因于细胞内铁血黄素（可能还有铜）的沉积，其产生不均匀的磁化率和优先的T2质子弛豫。在威尔逊病已知会发生脱髓鞘的区域，T2加权图像上也可见信号活动增强的区域。