The State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China.
J Mater Chem B. 2022 Jul 27;10(29):5520-5536. doi: 10.1039/d2tb01044e.
Stem cell therapy has shown unparalleled potential in tissue engineering, but it still faces challenges in the regulation of the stem cell fate. Inspired by the native stem cell niche, a variety of engineered hydrogels with programmed physicochemical properties have been developed to achieve flexible and controlled regulation of the stem cell fate, greatly enhancing the clinical application prospects of stem cell therapy in tissue regeneration. Here, the recent advances in hydrogels for stem cell therapy are summarized. The mechanism by which hydrogels regulate the stem cell fate is first presented, followed by the application of hydrogel/stem cell therapies in tissue engineering, including bone tissue engineering, skin wound healing and central nervous system regeneration. Finally, the current challenges and future prospects of hydrogel/stem cell therapies in tissue engineering are discussed. The purpose of this review is to provide a reference for the crossover and integration of hydrogels and stem cells in the field of tissue engineering.
干细胞治疗在组织工程中显示出无与伦比的潜力，但在调控干细胞命运方面仍面临挑战。受天然干细胞微环境的启发，已经开发出多种具有程序化物理化学特性的工程水凝胶，以实现对干细胞命运的灵活和可控调节，极大地增强了干细胞治疗在组织再生中的临床应用前景。本文总结了用于干细胞治疗的水凝胶的最新进展。首先介绍了水凝胶调控干细胞命运的机制，然后介绍了水凝胶/干细胞疗法在组织工程中的应用，包括骨组织工程、皮肤创伤愈合和中枢神经系统再生。最后，讨论了水凝胶/干细胞疗法在组织工程中的当前挑战和未来前景。本文的目的是为水凝胶和干细胞在组织工程领域的交叉和融合提供参考。
