West China School of Nursing/West China Hospital, Sichuan University, Chengdu 610041, PR China.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, PR China.
ACS Biomater Sci Eng. 2024 Apr 8;10(4):1921-1945. doi: 10.1021/acsbiomaterials.3c01485. Epub 2024 Mar 8.
The development of static hydrogels as an optimal choice for bone tissue engineering (BTE) remains a difficult challenge primarily due to the intricate nature of bone healing processes, continuous physiological functions, and pathological changes. Hence, there is an urgent need to exploit smart hydrogels with programmable properties that can effectively enhance bone regeneration. Increasing evidence suggests that photoresponsive hydrogels are promising bioscaffolds for BTE due to their advantages such as controlled drug release, cell fate modulation, and the photothermal effect. Here, we review the current advances in photoresponsive hydrogels. The mechanism of photoresponsiveness and its advanced applications in bone repair are also elucidated. Future research would focus on the development of more efficient, safer, and smarter photoresponsive hydrogels for BTE. This review is aimed at offering comprehensive guidance on the trends of photoresponsive hydrogels and shedding light on their potential clinical application in BTE.
将静态水凝胶开发为骨组织工程（BTE）的最佳选择仍然是一个具有挑战性的难题，主要是因为骨愈合过程、持续的生理功能和病理变化的复杂性。因此，迫切需要开发具有可编程特性的智能水凝胶，以有效促进骨再生。越来越多的证据表明，光响应水凝胶是 BTE 有前途的生物支架，因为它们具有诸如控制药物释放、细胞命运调节和光热效应等优点。在这里，我们回顾了光响应水凝胶的最新进展。阐明了光响应性的机制及其在骨修复中的先进应用。未来的研究将集中在开发更有效、更安全和更智能的用于 BTE 的光响应水凝胶上。本综述旨在提供关于光响应水凝胶趋势的全面指导，并阐明其在 BTE 中的潜在临床应用。
