Department of Obstetrics, Mianyang People's Hospital, Mianyang, Sichuan, China.
GenomCan Inc., Chengdu, Sichuan, China.
PLoS One. 2022 Jul 12;17(7):e0271219. doi: 10.1371/journal.pone.0271219. eCollection 2022.
To examine the association of fetal fraction with a wide spectrum of pregnancy-related complications among Chinese population, we carried out a single-institution retrospective cohort study of women with negative Noninvasive prenatal testing (NIPT) results and singleton pregnancies between May 2018 and May 2020. Indicators of pregnancy-related complications were examined individually, including preterm birth, low birth weight, hypertensive disorders of pregnancy, gestational diabetes, oligohydramnios and intrahepatic cholestasis. We evaluated disease odds ratios (ORs) and 95% confidence intervals (CIs), after controlling for potential confounders including body mass index (BMI), maternal age and gestational week at NIPT. A total of 3534 women were included in our analyses. Women with fetal fraction<15.15% had increased risk of gestational hypertension (OR 4.41, CI [1.65, 12.45]) and oligohydramnios (OR 2.26, CI [1.33, 3.80]) compared to women with fetal fraction≥15.15%. No significant associations with fetal fraction were found for preterm birth, low birth weight, gestational diabetes, and intrahepatic cholestasis. In Summary, fetal fraction is inversely associated with the risk of gestational hypertension and oligohydramnios.
为了研究胎儿分数与中国人群中一系列妊娠相关并发症的关系，我们进行了一项单中心回顾性队列研究，纳入了 2018 年 5 月至 2020 年 5 月间进行了阴性非侵入性产前检测（NIPT）且单胎妊娠的女性。单独检查了妊娠相关并发症的指标，包括早产、低出生体重、妊娠高血压疾病、妊娠期糖尿病、羊水过少和肝内胆汁淤积症。我们评估了疾病优势比（OR）及其 95%置信区间（CI），在控制了潜在混杂因素（包括体重指数（BMI）、母亲年龄和 NIPT 时的孕周）后进行分析。共有 3534 名女性纳入我们的分析。与胎儿分数≥15.15%的女性相比，胎儿分数<15.15%的女性发生妊娠高血压（OR 4.41，CI [1.65, 12.45]）和羊水过少（OR 2.26，CI [1.33, 3.80]）的风险增加。胎儿分数与早产、低出生体重、妊娠期糖尿病和肝内胆汁淤积症无显著相关性。总之，胎儿分数与妊娠高血压和羊水过少的风险呈负相关。
