Department of Gastroenterology, the First People's Hospital of Wenling, Wenling, China.
Department of General Surgery, Baoji Hospital, Baoji, China.
J Biomater Sci Polym Ed. 2022 Oct;33(15):1955-1972. doi: 10.1080/09205063.2022.2090348. Epub 2022 Jul 12.
Cancer targeted nanomaterials-based drug delivery systems have been described as promising. In this work, we employed silk fibroin (SF), ruthenium nanomaterials (RuNMs), heptapeptide (T7), and fingolimod (FTY720) to construct a pH-responsive smart nanomaterials drug delivery system. They were spherical with a mean size of around 120 nm, which may have contributed to the improved penetration and retention of the NMs in tumour areas. T7-FTY720@SF-RuNMs had an encapsulation efficiency (EE) of 72.51 ± 4.02%. When the pH of an environment is acidic, the release of FTY720 from nanocarriers is enhanced. T7-FTY720@SF-RuNMs demonstrated increased cellular uptake selective and anticancer efficacy for hepatocellular cancer in both and experiments. Additionally, the biodistribution investigation showed that T7-FTY720@SF-RuNMs could efficiently aggregate in the tumour location, improving their potential to kill cancer cells. T7-FTY720@SF-RuNMs demonstrated little toxicity to tumour-bearing animals in investigations of histology and immunohistochemistry, showing that the fabricated NMs are biocompatible . For the treatment of hepatocellular cancer, the T7-FTY720@SF-RuNMs delivery method offers significant promise.
基于癌症靶向的纳米材料的药物输送系统已被描述为很有前途。在这项工作中，我们采用丝素蛋白（SF）、钌纳米材料（RuNMs）、七肽（T7）和芬戈莫德（FTY720）构建了一种 pH 响应型智能纳米材料药物输送系统。它们呈球形，平均粒径约为 120nm，这可能有助于提高纳米材料在肿瘤区域的穿透和滞留能力。T7-FTY720@SF-RuNMs 的包封效率（EE）为 72.51±4.02%。当环境的 pH 值为酸性时，纳米载体中 FTY720 的释放会增强。T7-FTY720@SF-RuNMs 在 和 实验中均表现出对肝癌细胞更高的细胞摄取选择性和抗癌功效。此外， 生物分布研究表明，T7-FTY720@SF-RuNMs 能够在肿瘤部位有效聚集，提高其杀伤癌细胞的潜力。在组织学和免疫组织化学研究中，T7-FTY720@SF-RuNMs 对荷瘤动物的毒性很小，表明所制备的纳米材料具有良好的生物相容性。对于肝癌的治疗，T7-FTY720@SF-RuNMs 的给药方法具有很大的应用前景。
