Department of Exercise Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran.
Department of Sport Sciences, Khavaran Institute of Higher Education, Mashhad, Iran.
Can J Physiol Pharmacol. 2022 Sep 1;100(9):937-944. doi: 10.1139/cjpp-2021-0712. Epub 2022 Jul 12.
Adipose tissue browning is a physiological process that increases energy expenditure and may combat against obesity and its related risk factors. Fibroblast growth factor 21 (FGF21) and irisin, hormones affected by exercise that also affect adipose tissue browning, have not been widely studied with regard to exercise type and duration. This study compared the effect of high-intensity interval training (HIIT) and high-intensity resistance training (HIRT) on irisin and FGF21 in men living with overweight and obesity. After completing a training program three times weekly for 8 weeks, participants' serum levels of irisin and FGF21 were significantly increased in the HIIT and HIRT groups compared with the control group ( < 0.05). Additionally, body fat percentage and body weight in both training groups were significantly reduced in comparison with the control group ( < 0.05). Thus, HIIT and HIRT programs may be used as a feasible modality to promote favourable changes in body composition and irisin and FGF21, factors critical for browning white adipose tissue in men living with overweight and obesity.
脂肪组织棕色化是一种增加能量消耗的生理过程，可能有助于对抗肥胖及其相关危险因素。成纤维细胞生长因子 21（FGF21）和鸢尾素是受运动影响的激素，也会影响脂肪组织棕色化，但它们与运动类型和持续时间的关系尚未得到广泛研究。本研究比较了高强度间歇训练（HIIT）和高强度抗阻训练（HIRT）对超重和肥胖男性中鸢尾素和 FGF21 的影响。经过每周 3 次、持续 8 周的训练后，与对照组相比，HIIT 和 HIRT 组的血清鸢尾素和 FGF21 水平显著升高（<0.05）。此外，与对照组相比，两个训练组的体脂百分比和体重均显著降低（<0.05）。因此，HIIT 和 HIRT 方案可能可作为一种可行的方式，促进超重和肥胖男性体成分以及对白色脂肪组织棕色化至关重要的鸢尾素和 FGF21 的有利变化。
