Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Eur J Pharmacol. 2022 Aug 15;929:175147. doi: 10.1016/j.ejphar.2022.175147. Epub 2022 Jul 9.
Psoriasis is considered an autoimmune, inflammatory disorder with a genetic basis. The underlying aetiology is yet unclear. Evidence suggests the congregation of immune cells and their secreted inflammatory cytokines, leukocytes, and other inflammation-promoting factors in large amounts within the epidermal layers of the skin, driving an inflammatory milieu. Although psoriasis is not a fatal condition, patients experience severe pain and suffering. It has a debilitating effect on the physiological and psychological state of the patient. Its distinguishing features are inflammation, formation of plaques on the skin and hyperproliferation of keratinocytes. Therapeutic strategies for treating psoriasis witnessed a radical improvement from traditional therapies to the approval of specific therapies like biologics and small molecules. The emerging evidence about new pharmacological targets and mechanisms in psoriasis has widened the scope for expanding therapeutic strategies. Our review discusses the existing treatments for plaque psoriasis and updates on therapies based on novel pharmacological targets in clinical development.
银屑病被认为是一种具有遗传基础的自身免疫性炎症性疾病。其根本病因尚不清楚。有证据表明，大量免疫细胞及其分泌的炎症细胞因子、白细胞和其他促炎因子在皮肤表皮层聚集，导致炎症微环境。虽然银屑病不是致命的疾病，但患者会经历严重的疼痛和不适。它对患者的生理和心理状态有衰弱的影响。其特征是炎症、皮肤斑块形成和角质形成细胞过度增殖。治疗银屑病的策略从传统疗法到生物制剂和小分子等特定疗法的批准取得了根本性的改善。关于银屑病中新的药理靶点和机制的新证据拓宽了扩大治疗策略的范围。我们的综述讨论了斑块型银屑病的现有治疗方法，并更新了基于临床开发中新的药理靶点的治疗方法。
