Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
GI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Adv Exp Med Biol. 2023;1412:339-355. doi: 10.1007/978-3-031-28012-2_18.
Since the outbreak of the COVID-19 pandemic in December 2019, scientists worldwide have been looking for a way to control this global threat. One of the most successful and practical solutions has been the development and worldwide distribution of the COVID-19 vaccines. However, in a small percentage of cases, vaccination can lead to de novo development or exacerbation of immune or inflammatory conditions such as psoriasis. Due to the immunomodulatory nature of this disease, people affected by psoriasis and other related skin conditions have been encouraged to receive COVID-19 vaccines, which are immunomodulatory by nature. As such, dermatological reactions are possible in these patients, and cases of onset, exacerbation or change in the type of psoriasis have been observed in patients administered with COVID-19 vaccines. Considering the rarity and minor nature of some of these cutaneous reactions to COVID-19 vaccination, there is a general consensus that the benefits of vaccination outweigh the potential risks of experiencing such side effects. Nevertheless, healthcare workers who administer vaccines should be made aware of the potential risks and advise recipients accordingly. Furthermore, we suggest careful monitoring for potentially deleterious autoimmune and hyperinflammatory responses using point-of-care biomarker monitoring.
自 2019 年 12 月 COVID-19 大流行爆发以来，全球科学家一直在寻找控制这一全球威胁的方法。其中最成功和实用的解决方案之一是开发和在全球范围内分发 COVID-19 疫苗。然而，在极少数情况下，接种疫苗会导致新的免疫或炎症性疾病的发展或恶化，如银屑病。由于这种疾病的免疫调节性质，受银屑病和其他相关皮肤疾病影响的人被鼓励接种 COVID-19 疫苗，因为这些疫苗本身就具有免疫调节作用。因此，这些患者可能会出现皮肤反应，并且已经观察到在接种 COVID-19 疫苗的患者中出现银屑病的发病、恶化或类型改变的病例。考虑到一些这些对 COVID-19 疫苗接种的皮肤反应的罕见性和轻微性质，普遍认为接种疫苗的好处超过了经历这些副作用的潜在风险。然而，接种疫苗的医护人员应该意识到潜在的风险，并相应地向接种者提供建议。此外，我们建议使用即时生物标志物监测来仔细监测潜在的有害自身免疫和过度炎症反应。
