新生儿抗 Diego 抗体所致溶血病 1 例报告。
Neonatal hemolytic disease due to anti-Diego antibody: a case report.
机构信息
Department of Respiratory Medicine, Baoji Maternity and Child Health Care Hospital, Children's Hospital of Baoji, Affiliated Hospital of Shaanxi University of Chinese Medicine, Baoji, 721000, Shaanxi, China.
Department of Blood Transfusion, Baoji Maternity and Child Health Care Hospital, Children's Hospital of Baoji, Affiliated Hospital of Shaanxi University of Chinese Medicine, Baoji, 721000, Shaanxi, China.
出版信息
J Med Case Rep. 2022 Jul 13;16(1):274. doi: 10.1186/s13256-022-03516-2.
BACKGROUND
The Diego antigen commonly occurs in certain Asian and South American Indian populations. In general, hemolysis caused by anti-Diego antigen is not severe, and exchange transfusion is rarely needed. Here, we report a neonate with moderate hemolytic disease caused by anti-Diego antigen in the Baoji area of China.
CASE PRESENTATION
A 39-week gestation male newborn of Han nationality was delivered by second cesarean section because of scarred uterus. The newborn's birth weight was 3700 g with an Apgar score of 9. Four hours after delivery, transcutaneous bilirubin test revealed a level of 17 mg/dl. After 23 hours, the neonate developed anemia and hyperbilirubinemia. Bacterium, virus and other pathogens, as well as tests for arcuate and glucose-6-phosphate dehydrogenase, were all negative. Direct antiglobulin test of the neonate was positive. Diego antigens of the baby and his father were positive, while his mother was negative. The newborn was successfully cured with phototherapy and one-dose intravenous injection of human albumin.
CONCLUSIONS
It is important to consider and test for the anti-Diego antibody in cases of hemolytic disease of the newborn of the Han ethnicities of China.
背景
Diego 抗原通常存在于某些亚洲和南美洲印第安人群体中。一般来说，由抗 Diego 抗原引起的溶血并不严重，很少需要进行换血。在这里，我们报告了一例中国宝鸡地区因抗 Diego 抗原引起的新生儿中度溶血病。
病例介绍
一名 39 周龄汉族男性新生儿因瘢痕子宫行第二次剖宫产术娩出。新生儿出生体重 3700g，Apgar 评分为 9 分。出生后 4 小时，经皮胆红素测试显示胆红素水平为 17mg/dl。23 小时后，新生儿出现贫血和高胆红素血症。细菌、病毒等病原体以及弓形虫和葡萄糖-6-磷酸脱氢酶检测均为阴性。新生儿直接抗球蛋白试验阳性。婴儿及其父亲的 Diego 抗原阳性，而母亲的 Diego 抗原阴性。新生儿经光疗和一次静脉注射人血白蛋白成功治愈。
结论
在中国汉族新生儿溶血病的病例中，考虑和检测抗 Diego 抗体非常重要。
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