Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.
Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, 236-0004, Japan.
Sci Rep. 2022 Jul 11;12(1):11785. doi: 10.1038/s41598-022-16018-4.
This retrospective observational study analyzed the postoperative outcomes of bicanalicular intubation using different diameters of tube stents for treating postsaccal nasolacrimal duct obstruction. A total of 130 patients diagnosed with postsaccal obstruction who underwent endoscopic-assisted silicone tube intubation were included in the study. Patients intubated with a 1.5-mm large-diameter tube were designated as the LD group, and those with a 1.0-mm normal-diameter tube were designated as the ND group. The patency rates of the two groups at 1 year after tube removal were compared using the Kaplan-Meier curve and restricted mean survival time (RMST) method with τ = 365 days. Results demonstrated that the recurrence rate after tube removal was significantly lower in the LD group as compared with the ND group (p = 0.001). The patency rates at 1 year after removal in the LD and ND group were 85.7% (95% confidence interval [CI]: 75.4, 91.9) and 73.9% (95% CI: 61.7, 82.8), respectively. When comparing the patency rates by the RMST method at τ = 365 days, the RMST difference, RMST ratio, and RMTL ratio were higher in the LD group at p = 0.045, 0.052, and 0.046, respectively.
本回顾性观察研究分析了使用不同直径的管支架对治疗泪囊后段鼻泪管阻塞进行双管插管的术后结果。研究共纳入 130 例经诊断为泪囊后段阻塞并接受内镜辅助硅胶管插管的患者。使用 1.5mm 大直径管插管的患者被指定为 LD 组，使用 1.0mm 正常直径管插管的患者被指定为 ND 组。使用 Kaplan-Meier 曲线和受限平均生存时间（RMST）方法（τ=365 天）比较两组患者在去除管后 1 年的通畅率。结果表明，与 ND 组相比，LD 组去除管后的复发率显著降低（p=0.001）。LD 组和 ND 组在去除管后 1 年的通畅率分别为 85.7%（95%可信区间：75.4，91.9）和 73.9%（95%可信区间：61.7，82.8）。通过 RMST 方法比较在 τ=365 天时的通畅率，LD 组的 RMST 差异、RMST 比值和 RMTL 比值分别在 p=0.045、0.052 和 0.046 时更高。
