Ilves Norman, Laugesaar Rael, Rull Kristiina, Metsvaht Tuuli, Lintrop Mare, Laan Maris, Loorits Dagmar, Kool Pille, Ilves Pilvi
37544Radiology Clinic of Tartu University Hospital; Department of Radiology, Institute of Clinical Medicine, 37546University of Tartu, Tartu, Estonia.
37544Children's Clinic of Tartu University Hospital; Department of Pediatrics, Institute of Clinical Medicine, 37546University of Tartu, Tartu, Estonia.
J Child Neurol. 2022 Aug;37(8-9):677-688. doi: 10.1177/08830738221109340. Epub 2022 Jul 12.
The study was designed to assess the prevalence of pregnancy and delivery associated risk factors in children suffering from neonatal or presumed periventricular venous infarction. Antenatal records and pregnancy outcome data were retrospectively assessed in children with presumed periventricular venous infarction (n = 43, born ≥36 gestational weeks) or neonatal periventricular venous infarction (n = 86, born <36 gestational weeks) and compared to a matched control group (n = 2168, ≥36 gestational weeks) from a prospective study. Children with presumed periventricular venous infarction had significantly more maternal bacterial infections compared to the control group (47% vs 20%, respectively, < .001), whereas no difference was found compared to the neonatal periventricular venous infarction group (49%, = .80). Mothers with bacterial infection in the presumed periventricular venous infarction group had significantly more often pyelonephritis compared to the control group (50% vs 3.4%, respectively, < .001). Our data show an increased risk for developing periventricular venous infarction in the case of maternal bacterial infections, especially between gestational weeks 21 and 31.
本研究旨在评估患有新生儿或疑似脑室周围静脉梗死的儿童中与妊娠和分娩相关的危险因素的患病率。对疑似脑室周围静脉梗死儿童（n = 43，孕周≥36周出生）或新生儿脑室周围静脉梗死儿童（n = 86，孕周<36周出生）的产前记录和妊娠结局数据进行回顾性评估，并与一项前瞻性研究中的匹配对照组（n = 2168，孕周≥36周）进行比较。与对照组相比，疑似脑室周围静脉梗死的儿童母亲细菌感染明显更多（分别为47%和20%，<0.001），而与新生儿脑室周围静脉梗死组相比未发现差异（49%，P = 0.80）。疑似脑室周围静脉梗死组中患有细菌感染的母亲肾盂肾炎的发生率明显高于对照组（分别为50%和3.4%，<0.001）。我们的数据显示，母亲发生细菌感染时，尤其是在孕21至31周之间，发生脑室周围静脉梗死的风险增加。
