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围手术期阿片类药物咨询可减少初次全关节置换术后阿片类药物的使用。

Perioperative Opioid Counseling Reduces Opioid Use Following Primary Total Joint Arthroplasty.

机构信息

Department of Orthopedics and Rehabilitation, University of Iowa Hospitals & Clinics, Iowa City, Iowa, USA.

Penn Orthopaedics, Penn Medicine, Philadelphia, Pennsylvania, USA.

出版信息

Iowa Orthop J. 2022 Jun;42(1):169-177.

Abstract

BACKGROUND

Preoperative counseling may reduce postoperative opioid requirements; however, there is a paucity of randomized controlled trials (RCTs) demonstrating efficacy. The purpose of this study was to perform an interventional, telehealth-based RCT evaluating the effect of peri-operative counseling on quantity and duration of opioid consumption following primary total joint arthroplasty (TJA).

METHODS

Participants were randomized into three groups: 1. Control group, no perioperative counseling; 2. Intervention group, preoperative educational video; 3. Intervention group, preoperative educational video and postoperative acceptance and commitment therapy (ACT). Opioid consumption was evaluated daily for 14 days and at 6 weeks postoperatively. Best-case and worse-case intention to treat analyses were performed to account for non-responses. Bonferroni corrections were applied.

RESULTS

183 participants were analyzed (63 in Group 1, 55 in Group 2, and 65 in Group 3). At 2 weeks postoperatively, there was no difference in opioid consumption between Groups 1, 2, and 3 (p>0.05 for all). At 6 weeks postoperatively, Groups 2 and 3 had consumed significantly less opioids than Group 1 (p=0.04, p<0.001) (Table 1). Group 3 participants were less likely to obtain an opioid refill relative to Group 1 participants (p=0.04). Participants in groups 2 and 3 ceased opioid consumption a median of 6 days and 2 days sooner than Group 1, respectively (p<0.001, p=0.03) (Table 2).

CONCLUSION

Perioperative opioid counseling significantly decreases the quantity and duration of opioid consumption at 6 weeks following primary TJA. .

摘要

背景

术前咨询可能会减少术后阿片类药物的需求;然而,目前缺乏随机对照试验(RCT)来证明其疗效。本研究的目的是进行一项干预性、基于远程医疗的 RCT,评估围手术期咨询对初次全关节置换术(TJA)后阿片类药物使用量和持续时间的影响。

方法

参与者被随机分为三组:1. 对照组,无围手术期咨询;2. 干预组,术前教育视频;3. 干预组,术前教育视频和术后接受和承诺疗法(ACT)。术后 14 天和 6 周评估阿片类药物的使用量。采用最佳和最差情况意向治疗分析来解释非应答情况。采用 Bonferroni 校正。

结果

183 名参与者进行了分析(第 1 组 63 名,第 2 组 55 名,第 3 组 65 名)。术后 2 周,三组间阿片类药物使用量无差异(p>0.05)。术后 6 周,第 2 组和第 3 组的阿片类药物消耗量明显低于第 1 组(p=0.04,p<0.001)(表 1)。与第 1 组相比,第 3 组参与者获得阿片类药物续药的可能性较低(p=0.04)。第 2 组和第 3 组参与者停止阿片类药物使用的中位数分别比第 1 组早 6 天和 2 天(p<0.001,p=0.03)(表 2)。

结论

围手术期阿片类药物咨询显著减少初次 TJA 后 6 周内阿片类药物的使用量和持续时间。

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