Department of Orthopedics and Rehabilitation, University of Iowa Hospitals & Clinics, Iowa City, Iowa, USA.
Penn Orthopaedics, Penn Medicine, Philadelphia, Pennsylvania, USA.
Iowa Orthop J. 2022 Jun;42(1):169-177.
Preoperative counseling may reduce postoperative opioid requirements; however, there is a paucity of randomized controlled trials (RCTs) demonstrating efficacy. The purpose of this study was to perform an interventional, telehealth-based RCT evaluating the effect of peri-operative counseling on quantity and duration of opioid consumption following primary total joint arthroplasty (TJA).
Participants were randomized into three groups: 1. Control group, no perioperative counseling; 2. Intervention group, preoperative educational video; 3. Intervention group, preoperative educational video and postoperative acceptance and commitment therapy (ACT). Opioid consumption was evaluated daily for 14 days and at 6 weeks postoperatively. Best-case and worse-case intention to treat analyses were performed to account for non-responses. Bonferroni corrections were applied.
183 participants were analyzed (63 in Group 1, 55 in Group 2, and 65 in Group 3). At 2 weeks postoperatively, there was no difference in opioid consumption between Groups 1, 2, and 3 (p>0.05 for all). At 6 weeks postoperatively, Groups 2 and 3 had consumed significantly less opioids than Group 1 (p=0.04, p<0.001) (Table 1). Group 3 participants were less likely to obtain an opioid refill relative to Group 1 participants (p=0.04). Participants in groups 2 and 3 ceased opioid consumption a median of 6 days and 2 days sooner than Group 1, respectively (p<0.001, p=0.03) (Table 2).
Perioperative opioid counseling significantly decreases the quantity and duration of opioid consumption at 6 weeks following primary TJA. .
术前咨询可能会减少术后阿片类药物的需求;然而,目前缺乏随机对照试验(RCT)来证明其疗效。本研究的目的是进行一项干预性、基于远程医疗的 RCT,评估围手术期咨询对初次全关节置换术(TJA)后阿片类药物使用量和持续时间的影响。
参与者被随机分为三组:1. 对照组,无围手术期咨询;2. 干预组,术前教育视频;3. 干预组,术前教育视频和术后接受和承诺疗法(ACT)。术后 14 天和 6 周评估阿片类药物的使用量。采用最佳和最差情况意向治疗分析来解释非应答情况。采用 Bonferroni 校正。
183 名参与者进行了分析(第 1 组 63 名,第 2 组 55 名,第 3 组 65 名)。术后 2 周,三组间阿片类药物使用量无差异(p>0.05)。术后 6 周,第 2 组和第 3 组的阿片类药物消耗量明显低于第 1 组(p=0.04,p<0.001)(表 1)。与第 1 组相比,第 3 组参与者获得阿片类药物续药的可能性较低(p=0.04)。第 2 组和第 3 组参与者停止阿片类药物使用的中位数分别比第 1 组早 6 天和 2 天(p<0.001,p=0.03)(表 2)。
围手术期阿片类药物咨询显著减少初次 TJA 后 6 周内阿片类药物的使用量和持续时间。