Bratus' G G, Darchuk G F, Komissarenko V G, Nastenko E P
Eksp Onkol. 1987;9(2):36-40.
Vibrio cholerici neuraminidase was studied on CBA mice for its effect on the strain NK/Ly lymphoid cells oncogenicity in intraabdominal transplantation. The 30% decrease in transplantability of cells treated by the enzyme in the dose of 50 U/ml was established. The modulating effect of specific active immunotherapy by modified cells in lymphoma was also studied. A pronounced stimulation of immunity T-cell links and proliferation in immunocompetent organs, an increase in the number of large granular lymphocytes in blood, specific antibody formation suppression were established. The problem of neuraminidase nonspecific effect on the tumour cells is under discussion.
研究了霍乱弧菌神经氨酸酶对CBA小鼠腹腔内移植的NK/Ly淋巴样细胞致癌性的影响。确定了用50 U/ml剂量的该酶处理的细胞移植性降低了30%。还研究了经修饰的细胞进行特异性主动免疫疗法对淋巴瘤的调节作用。确定了对免疫T细胞连接和免疫活性器官增殖有明显刺激作用，血液中大颗粒淋巴细胞数量增加，特异性抗体形成受到抑制。正在讨论神经氨酸酶对肿瘤细胞的非特异性作用问题。
