Shapovalova S P, Aleksander S K, Liashenko V A
Antibiotiki. 1981 Apr;26(4):302-6.
Sensitivity of the mice inoculated with ascitic NK/Ly cells and cured with carminomycin to repeated inoculation with the same tumour was studied. It was found that curing with carminomycin was accompanied by development of resistance to the repeated inoculation. Such resistance might be transferred to intact singeneic mice with a suspension of the cells of the spleen or lymph nodes from unsusceptible donors. The transfer of the thymus cells from the above donors protected the recipients only partially. The spleen cells from intact donors, as well as their lymph node cells did not inhibit the tumour development. The thymus cells of the intact mice induced some suppression, thus probably favouring the active immune response in the recipient. Curing of the NK/Ly-inoculated mice with carminomycin was a more effective method for induction of immunity to the tumour than immunization of mice with NK/Ly cells inactivated by UV irradiation in vitro
研究了接种腹水NK/Ly细胞并用卡米诺霉素治愈的小鼠对相同肿瘤重复接种的敏感性。发现用卡米诺霉素治愈伴随着对重复接种产生抗性。这种抗性可以通过将来自不易感供体的脾脏或淋巴结细胞悬液转移给完整的同基因小鼠而转移。来自上述供体的胸腺细胞转移仅部分保护受体。来自完整供体的脾脏细胞及其淋巴结细胞不抑制肿瘤发展。完整小鼠的胸腺细胞诱导了一些抑制作用，因此可能有利于受体中的主动免疫反应。用卡米诺霉素治愈接种NK/Ly的小鼠比用体外紫外线照射灭活的NK/Ly细胞免疫小鼠是诱导肿瘤免疫的更有效方法。
