Pirrotta V, Manet E, Hardon E, Bickel S E, Benson M
EMBO J. 1987 Mar;6(3):791-9. doi: 10.1002/j.1460-2075.1987.tb04821.x.
The zeste gene of Drosophila affects the expression of other genes in a manner that depends on the homologous pairing of the chromosomes bearing the target gene. Zeste mediates transvection effects, the ability of one gene to control the expression of its homologous copy on another chromosome. We have determined the structure of the zeste gene and several mutants bearing partial deletions and the sequence of the z+, z1, zop6 and z11G3 alleles. The predicted zeste protein has an unusual structure including runs of Gln, Ala and alternating Gln Ala. Contrary to expectations the z1, zop6 and z11G3 mutations can each be attributed to single amino acid changes. The analysis of the mutants suggests that the zeste gene product is required for normal expression of at least some genes and we argue that za mutants may have residual function.
果蝇的zeste基因以一种依赖于携带目标基因的染色体同源配对的方式影响其他基因的表达。Zeste介导转位效应，即一个基因控制其在另一条染色体上同源拷贝表达的能力。我们已经确定了zeste基因的结构以及几个带有部分缺失的突变体，还有z+、z1、zop6和z11G3等位基因的序列。预测的zeste蛋白具有不寻常的结构，包括谷氨酰胺、丙氨酸的重复序列以及谷氨酰胺和丙氨酸的交替序列。与预期相反，z1、zop6和z11G3突变均可归因于单个氨基酸变化。对这些突变体的分析表明，zeste基因产物是至少某些基因正常表达所必需的，并且我们认为za突变体可能具有残余功能。
