斑白相互作用：一类新型斑白等位基因的诱导和遗传分析。
The zeste-white interaction: induction and genetic analysis of a novel class of zeste alleles.
机构信息
Department of Biology, TECHNION-Israel Institute of Technology, Haifa, Israel.
出版信息
EMBO J. 1984 May;3(5):999-1002. doi: 10.1002/j.1460-2075.1984.tb01919.x.
Abstract
The recovery and analysis of a novel class of zeste mutations is described. z and z do not require two w genes for their expression unless the z gene is present. Analysis of genetic interactions among zeste alleles proved that z mutations are strong antagonists of the z gene product. z is readily reverted by X-rays or by ethylmethane sulphonate to a range of intermediate zeste alleles and thus it is considered to be an insertional mutation. We suggest that z and op mutations arose as a result of insertions in a presumptive control region, and two alternative models for the structure of the zeste locus are evaluated.
摘要
描述了一类新型 zeste 突变的恢复和分析。z 和 z 不需要两个 w 基因来表达，除非存在 z 基因。对 zeste 等位基因之间的遗传相互作用的分析证明，z 突变是 z 基因产物的强拮抗剂。z 很容易被 X 射线或乙基甲烷磺酸逆转成一系列中间 zeste 等位基因，因此它被认为是插入突变。我们认为 z 和 op 突变是由于在一个假定的控制区域的插入而产生的，并且评估了 zeste 基因座的两种替代结构模型。
相似文献
1
The zeste-white interaction: induction and genetic analysis of a novel class of zeste alleles.斑白相互作用：一类新型斑白等位基因的诱导和遗传分析。
EMBO J. 1984 May;3(5):999-1002. doi: 10.1002/j.1460-2075.1984.tb01919.x.
2
The effects of chromosomal rearrangements on the zeste-white interaction in Drosophila melanogaster.染色体重排在黑腹果蝇中对小体-白色相互作用的影响。
Genetics. 1987 Jun;116(2):285-98. doi: 10.1093/genetics/116.2.285.
3
Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogaster.果蝇中zeste基因座增强子的遗传分析及其在基因调控中的作用。
Genetics. 1990 Sep;126(1):185-99. doi: 10.1093/genetics/126.1.185.
4
Identification of mutations in three genes that interact with zeste in the control of white gene expression in Drosophila melanogaster.在黑腹果蝇中，鉴定在白色基因表达调控中与zeste相互作用的三个基因中的突变。
Genetics. 1994 Nov;138(3):733-9. doi: 10.1093/genetics/138.3.733.
5
Interactions between WHITE Genes Carried by a Large Transposing Element and the ZESTE Allele in DROSOPHILA MELANOGASTER.转座因子携带的 WHITE 基因与果蝇 ZESTE 等位基因的相互作用。
Genetics. 1986 Mar;112(3):551-75. doi: 10.1093/genetics/112.3.551.
6
Isolation and characterization of the zeste locus of Drosophila.果蝇 zeste 基因座的分离与鉴定。
EMBO J. 1985 Aug;4(8):2045-52. doi: 10.1002/j.1460-2075.1985.tb03890.x.
7
Allelic pairing and gene regulation: A model for the zeste-white interaction in Drosophila melanogaster.等位基因配对与基因调控：黑腹果蝇中zeste-white相互作用的模型。
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1368-72. doi: 10.1073/pnas.76.3.1368.
8
Interactions of zeste mutations with loci exhibiting transvection effects in Drosophila melanogaster.果蝇中zeste突变与表现出转位效应的基因座之间的相互作用。
Genetics. 1982 Oct;102(2):179-89. doi: 10.1093/genetics/102.2.179.
9
Effect of storage and dose on MMS-induced deletions. Complementation analysis of X-chromosomal recessive lethals in the zeste-white and maroon-like regions of Drosophila melanogaster.储存和剂量对甲基磺酸甲酯诱导的缺失的影响。果蝇黑腹果蝇zeste-white和maroon-like区域X染色体隐性致死基因的互补分析。
Mutat Res. 1983 Oct;111(2):145-59. doi: 10.1016/0027-5107(83)90059-3.
10
Structure and sequence of the Drosophila zeste gene.果蝇zeste基因的结构与序列
EMBO J. 1987 Mar;6(3):791-9. doi: 10.1002/j.1460-2075.1987.tb04821.x.
引用本文的文献
1
Expression of the Drosophila white gene under the control of the hsp70 heat shock promoter.在 hsp70 热休克启动子的控制下，果蝇 white 基因的表达。
EMBO J. 1985 Dec 30;4(13B):3765-72. doi: 10.1002/j.1460-2075.1985.tb04146.x.
2
Isolation and characterization of the zeste locus of Drosophila.果蝇 zeste 基因座的分离与鉴定。
EMBO J. 1985 Aug;4(8):2045-52. doi: 10.1002/j.1460-2075.1985.tb03890.x.
3
An FB-NOF mediated duplication of the white gene is responsible for the zeste1 phenotype in some Drosophila melanogaster unstable strains.在一些黑腹果蝇不稳定品系中，FB-NOF介导的白色基因重复导致了zeste1表型。
Mol Genet Genomics. 2006 Jan;275(1):35-43. doi: 10.1007/s00438-005-0068-6. Epub 2005 Dec 7.
4
Multimerization of the Drosophila zeste protein is required for efficient DNA binding.果蝇zeste蛋白的多聚化是有效DNA结合所必需的。
EMBO J. 1993 May;12(5):2075-83. doi: 10.1002/j.1460-2075.1993.tb05856.x.
5
Stepwise assembly of hyperaggregated forms of Drosophila zeste mutant protein suppresses white gene expression in vivo.果蝇小体突变蛋白超聚集形式的逐步组装在体内抑制白色基因的表达。
EMBO J. 1993 May;12(5):2061-73. doi: 10.1002/j.1460-2075.1993.tb05855.x.
6
Structure and sequence of the Drosophila zeste gene.果蝇zeste基因的结构与序列
EMBO J. 1987 Mar;6(3):791-9. doi: 10.1002/j.1460-2075.1987.tb04821.x.
7
Molecular cloning, germ-line transformation, and transcriptional analysis of the zeste locus of Drosophila melanogaster.黑腹果蝇zeste基因座的分子克隆、种系转化及转录分析。
Proc Natl Acad Sci U S A. 1986 Feb;83(3):701-5. doi: 10.1073/pnas.83.3.701.
8
Multiple upstream regulatory elements control the expression of the Drosophila white gene.多个上游调控元件控制果蝇白眼基因的表达。
EMBO J. 1985 Dec 16;4(13A):3501-8. doi: 10.1002/j.1460-2075.1985.tb04109.x.
9
Separable cis-acting control elements for expression of the white gene of Drosophila.果蝇白色基因表达的可分离顺式作用控制元件。
EMBO J. 1985 Dec 16;4(13A):3489-99. doi: 10.1002/j.1460-2075.1985.tb04108.x.
10
Self-association of the Drosophila zeste protein is responsible for transvection effects.果蝇zeste蛋白的自我缔合导致了转座效应。
EMBO J. 1990 Sep;9(9):2959-67. doi: 10.1002/j.1460-2075.1990.tb07488.x.
本文引用的文献
1
Allelic pairing and gene regulation: A model for the zeste-white interaction in Drosophila melanogaster.等位基因配对与基因调控：黑腹果蝇中zeste-white相互作用的模型。
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1368-72. doi: 10.1073/pnas.76.3.1368.
2
Formation of duplication-deficiency products by asymmetrical exchange within a complex locus of Drosophila melanogaster.通过黑腹果蝇复杂基因座内的不对称交换形成重复-缺失产物。
Proc Natl Acad Sci U S A. 1961 Apr 15;47(4):545-50. doi: 10.1073/pnas.47.4.545.
3
Interactions of zeste mutations with loci exhibiting transvection effects in Drosophila melanogaster.果蝇中zeste突变与表现出转位效应的基因座之间的相互作用。
Genetics. 1982 Oct;102(2):179-89. doi: 10.1093/genetics/102.2.179.
4
A genetic analysis of the killer-prune (K-pn) locus of Drosophila melanogaster.黑腹果蝇杀手-修剪（K-pn）基因座的遗传分析。
Genetics. 1969 Jun;62(2):353-8. doi: 10.1093/genetics/62.2.353.
5
Ancient linkage groups and frozen accidents.古老的连锁群与固定的偶然事件。
Nature. 1973 Aug 3;244(5414):259-62. doi: 10.1038/244259a0.
6
Loss of duplicate gene expression after polyploidisation.多倍体化后重复基因表达的丧失。
Nature. 1977 Jan 20;265(5591):258-60. doi: 10.1038/265258a0.
7
A revision of the cytology and ontogeny of several deficiencies in the 3A1-3C6 region of the X chromosome of Drosophila melanogaster.黑腹果蝇X染色体3A1 - 3C6区域若干缺失的细胞学及个体发生学修订
Genetics. 1975 Feb;79(2):265-82. doi: 10.1093/genetics/79.2.265.
8
Genetic instability in Drosophila melanogaster: tandem duplications as monitors of intrastrand exchange.黑腹果蝇中的遗传不稳定性：串联重复作为链内交换的监测指标。
Chromosoma. 1979 Oct 1;74(3):329-35. doi: 10.1007/BF01190747.
9
Genetic identification of dominant overproducing mutations: the Beadex gene.显性高产突变的基因鉴定：Beadex基因
Mol Gen Genet. 1979 Mar 20;171(2):153-9. doi: 10.1007/BF00270001.
Zotero 插件