Koenig A, Koenig U D, Binhold B, Stoeckel H
Eur J Anaesthesiol. 1987 Jan;4(1):25-33.
In this study, neuroleptanaesthesia reduced the reactivity of lymphocytes to phytohaemagglutin (PHA-P) and pokeweed mitogen (PWM) in patients in a manner similar to that seen with halothane/nitrous oxide and enflurane/nitrous oxide inhalational anaesthesia. These findings began 4 h post-operatively, lasted throughout the first post-operative day and were similar in both operative trauma groups (eye surgery/gynaecological surgery). However, unlike the situation with the inhalational agent, Concanavalin A (Con A)-induced proliferation did not alter. It was also noted that, on the third post-operative day in both trauma groups, PHA-P- and PWM-induced proliferation ratios were significantly higher than were the pre-operative values. These findings could be the result of a specific effect of neuroleptanaesthesia.
在本研究中，神经安定麻醉降低了患者淋巴细胞对植物血凝素（PHA-P）和商陆有丝分裂原（PWM）的反应性，其方式类似于氟烷/氧化亚氮和恩氟烷/氧化亚氮吸入麻醉所见。这些发现于术后4小时开始，持续整个术后第一天，且在两个手术创伤组（眼科手术/妇科手术）中相似。然而，与吸入剂的情况不同，刀豆球蛋白A（Con A）诱导的增殖没有改变。还注意到，在两个创伤组的术后第三天，PHA-P和PWM诱导的增殖率显著高于术前值。这些发现可能是神经安定麻醉特定作用的结果。
