Koenig A, Koenig U D, Heicappel R, Stoeckel H
Eur J Anaesthesiol. 1987 Jan;4(1):17-24.
Cell-mediated immunity (investigated by in vitro mitogen/antigen induced lymphocyte proliferation) is known to be depressed in the post-operative period. In the present investigation, performed with halothane/nitrous oxide inhalational anaesthesia in healthy patients without trauma (eye surgery) and with operative tissue trauma (gynaecological operations), only the combination of major surgery with halothane/nitrous oxide anaesthesia was associated with a depression of lymphocyte reactivity to phytohaemagglutin (PHA-P), Concanavalin A (Con A) and pokeweed mitogen (PWM). This lasted for 3-10 days post-operatively.
细胞介导的免疫（通过体外丝裂原/抗原诱导的淋巴细胞增殖来研究）在术后阶段会受到抑制。在本研究中，对无创伤的健康患者（眼科手术）以及有手术组织创伤的患者（妇科手术）采用氟烷/氧化亚氮吸入麻醉，结果发现只有大手术联合氟烷/氧化亚氮麻醉会导致淋巴细胞对植物血凝素（PHA-P）、刀豆蛋白A（Con A）和商陆有丝分裂原（PWM）的反应性降低。这种情况在术后持续3至10天。
