Jensen T, Borch-Johnsen K, Kofoed-Enevoldsen A, Deckert T
Diabetologia. 1987 Mar;30(3):144-8. doi: 10.1007/BF00274218.
Fifty-nine Type 1 (insulin-dependent) diabetic patients with (group I) and 59 patients without nephropathy (group II) pair-matched according to sex (30 males and 29 females), age (33 years, range 15-48) and diabetes duration (19 years, range 6-42) were followed for a period of 10 years from about 5 years before to 5 years after onset of proteinuria. The cumulative incidence of coronary heart disease was estimated, and blood pressure and serum cholesterol were followed. Within six years after onset of proteinuria the cumulative incidence of coronary heart disease was increased eight-fold in group I (40%) compared with group II (5%), (p less than 0.001). Blood pressure was higher in group I compared with group II from before onset of proteinuria (135/86 +/- 17/9 mmHg vs 129/80 +/- 15/8 mmHg, p less than 0.001), and serum cholesterol elevated from onset of proteinuria in group I (6.3 +/- 1.2 mmol/l) vs. group II (5.5 +/- 1.0 mmol/l), (p less than 0.005). Patients in group I who developed coronary heart disease had similar age (36 years, range 21-51, vs 38 years, range 21-53), sex (50% males vs. 52% males), smoking frequency (50% vs 49%), diabetes duration (22 years, range 9-39, vs 24 years, range 10-42) and serum creatinine (110 mumol/l, range 69-284, vs 108 mumol, range 72-1024) compared with patients not developing coronary heart disease.(ABSTRACT TRUNCATED AT 250 WORDS)
59例1型（胰岛素依赖型）糖尿病肾病患者（I组）和59例无肾病的患者（II组），根据性别（30例男性和29例女性）、年龄（33岁，范围15 - 48岁）和糖尿病病程（19年，范围6 - 42年）进行配对。从蛋白尿出现前约5年到出现后5年，对这些患者进行了为期10年的随访。估计冠心病的累积发病率，并监测血压和血清胆固醇。蛋白尿出现后6年内，I组冠心病的累积发病率（40%）相比II组（5%）增加了8倍（p<0.001）。蛋白尿出现前I组的血压高于II组（135/86±17/9 mmHg对129/80±15/8 mmHg，p<0.001），I组血清胆固醇从蛋白尿出现时开始升高（6.3±1.2 mmol/l），而II组为（5.5±1.0 mmol/l）（p<0.005）。与未患冠心病的患者相比，I组中患冠心病的患者在年龄（36岁，范围21 - 51岁，对38岁，范围21 - 53岁）、性别（男性50%对男性52%）、吸烟频率（50%对49%）、糖尿病病程（22年，范围9 - 39年，对24年，范围10 - 42年）和血清肌酐（110 μmol/l，范围69 - 284，对108 μmol，范围72 - 1024）方面相似。（摘要截短于250字）
