. Divisão de Pneumologia, Instituto do Coração - InCor - Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.
. Consultoria Médica e Pesquisa Clínica - CMPC - Sorocaba (SP) Brasil.
J Bras Pneumol. 2022 Jul 8;48(3):e20210367. doi: 10.36416/1806-3756/e20210367. eCollection 2022.
To assess the prevalence of the eosinophilic and allergic phenotypes of severe asthma in Brazil, as well as to investigate the clinical characteristics of severe asthma patients in the country.
This was a cross-sectional study of adult patients diagnosed with severe asthma and managed at specialized centers in Brazil. The study was conducted in 2019.
A total of 385 patients were included in the study. Of those, 154 had a blood eosinophil count > 300 cells/mm3 and 231 had a blood eosinophil count of ≤ 300 cells/mm3. The median age was 54.0 years, and most of the patients were female, with a BMI of 29.0 kg/m2 and a history of allergy (81.6%). The prevalence of patients with a blood eosinophil count > 300 cells/mm3 was 40.0% (95% CI: 35.1-44.9), and that of those with a blood eosinophil count > 300 cells/mm3 and a history of allergy was 31.9% (95% CI: 27.3-36.6). Age and BMI showed positive associations with a blood eosinophil count > 300 cells/mm3 (OR = 0.97, p < 0.0001; and OR = 0.96, p = 0.0233, respectively), whereas the time elapsed since the onset of asthma symptoms showed an increased association with a blood eosinophil count > 300 cells/mm3 (OR = 1.02, p = 0.0011).
This study allowed us to characterize the population of severe asthma patients in Brazil, showing the prevalence of the eosinophilic phenotype (in 40% of the sample). Our results reveal the relevance of the eosinophilic phenotype of severe asthma at a national level, contributing to increased effectiveness in managing the disease and implementing public health strategies.
评估巴西严重哮喘嗜酸性粒细胞和过敏表型的流行情况，并研究该国严重哮喘患者的临床特征。
这是一项巴西专门中心管理的成人严重哮喘患者的横断面研究。该研究于 2019 年进行。
共有 385 名患者纳入研究。其中，154 名患者血液嗜酸性粒细胞计数>300 细胞/mm3，231 名患者血液嗜酸性粒细胞计数≤300 细胞/mm3。中位年龄为 54.0 岁，大多数患者为女性，BMI 为 29.0kg/m2，有过敏史（81.6%）。血液嗜酸性粒细胞计数>300 细胞/mm3 的患者患病率为 40.0%（95%CI：35.1-44.9），血液嗜酸性粒细胞计数>300 细胞/mm3 且有过敏史的患者患病率为 31.9%（95%CI：27.3-36.6）。年龄和 BMI 与血液嗜酸性粒细胞计数>300 细胞/mm3 呈正相关（OR=0.97，p<0.0001；和 OR=0.96，p=0.0233），而哮喘症状发作后时间与血液嗜酸性粒细胞计数>300 细胞/mm3 呈正相关（OR=1.02，p=0.0011）。
本研究对巴西严重哮喘患者人群进行了特征描述，显示了嗜酸性粒细胞表型的流行率（在样本的 40%中）。我们的结果揭示了国家层面严重哮喘嗜酸性粒细胞表型的重要性，有助于提高疾病管理的效果，并实施公共卫生策略。
