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2020 年巴西胸科协会哮喘管理建议。

2020 Brazilian Thoracic Association recommendations for the management of asthma.

机构信息

. Programa de Pós-Graduação em Ciências Médicas, Universidade Federal de Santa Catarina - UFSC - Florianópolis (SC) Brasil.

. Divisão de Pneumologia, Instituto do Coração - InCor - Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.

出版信息

J Bras Pneumol. 2020 Mar 2;46(1):e20190307. doi: 10.1590/1806-3713/e20190307. eCollection 2020.

Abstract

The pharmacological management of asthma has changed considerably in recent decades, as it has come to be understood that it is a complex, heterogeneous disease with different phenotypes and endotypes. It is now clear that the goal of asthma treatment should be to achieve and maintain control of the disease, as well as to minimize the risks (of exacerbations, disease instability, accelerated loss of lung function, and adverse treatment effects). That requires an approach that is personalized in terms of the pharmacological treatment, patient education, written action plan, training in correct inhaler use, and review of the inhaler technique at each office visit. A panel of 22 pulmonologists was invited to perform a critical review of recent evidence of pharmacological treatment of asthma and to prepare this set of recommendations, a treatment guide tailored to use in Brazil. The topics or questions related to the most significant changes in concepts, and consequently in the management of asthma in clinical practice, were chosen by a panel of experts. To formulate these recommendations, we asked each expert to perform a critical review of a topic or to respond to a question, on the basis of evidence in the literature. In a second phase, three experts discussed and structured all texts submitted by the others. That was followed by a third phase, in which all of the experts reviewed and discussed each recommendation. These recommendations, which are intended for physicians involved in the treatment of asthma, apply to asthma patients of all ages.

摘要

在过去的几十年中,哮喘的药理学管理发生了重大变化,因为人们逐渐认识到哮喘是一种复杂的、异质的疾病,具有不同的表型和内型。现在已经清楚,哮喘治疗的目标应该是实现并维持疾病的控制,同时最大限度地降低(加重、疾病不稳定、肺功能加速丧失和治疗不良反应)的风险。这需要一种针对药理学治疗、患者教育、书面行动计划、正确使用吸入器的培训以及每次就诊时对吸入器技术进行评估的个性化方法。一组 22 名肺病专家应邀对哮喘的药理学治疗的最新证据进行批判性审查,并编写了这套建议,这是一份针对巴西使用情况量身定制的治疗指南。与概念上的重大变化以及因此在临床实践中对哮喘的管理相关的主题或问题是由一组专家选择的。为了制定这些建议,我们要求每位专家根据文献中的证据对某个主题进行批判性审查或对某个问题做出回应。在第二阶段,三位专家讨论并构建了其他专家提交的所有文本。随后进行了第三阶段,所有专家都对每条建议进行了审查和讨论。这些建议适用于所有年龄段的哮喘患者,供参与哮喘治疗的医生使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8a00/7462684/f561b184cf40/1806-3713-jbpneu-46-01-e20190307-gf1.jpg

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