Universidade Federal do Piauí - UFPI, Department of Pathology and Dental Clinics, Teresina, PI, Brazil.
Universidade de São Paulo - USP, School of Dentistry, Department of Pediatric Dentistry, São Paulo, SP, Brazil.
Braz Oral Res. 2022 Jul 11;36:e099. doi: 10.1590/1807-3107bor-2022.vol36.0099. eCollection 2022.
The aim of this study was to evaluate the clinical efficacy of varnish and neutral fluoride gel in the management of early childhood caries (ECC). A randomized clinical trial was conducted to compare two strategies for ECC management: topical application of neutral fluoride gel (NFG group) and varnish (FV group) every four months for a period of one year. The sample consisted of children between the ages of three and four years, enrolled in public daycare centers. The incidence of ECC between the groups was compared by assessing values (new dmfs) at two levels: d2 when enamel/dentin were affected and d3 when dentin affected. Pearson's Chi-square, Fisher's Exact, Kolmogorov-Smirnov and Mann-Whitney tests were used to compare the incidence and increment of caries between the NFG and FV groups (p<0.05). A total of 240 children were included in this study and 213 children (88.7%) were followed up for 12 months. The incidence of ECC was 24.1% in the GF and 21.0% in the FV groups (p=0.586). The increment of caries in d2mfs was 1.36 (95% CI = 0.83 - 1.89) in the NFG and 1.33 (95% CI = 0.75 - 1.89) in FV (p=0.756) groups. Increment of caries in d3mfs was 1.60 (95% CI = 0.95 - 2.25) in NFG and 1.40 (95% CI = 0.75 - 2.04) in FV (p=0.468). Neutral fluoride gel and fluoride varnish exhibited similar efficacy in the management of ECC after 12 months of follow-up.
本研究旨在评估涂料和中性氟化物凝胶在幼儿龋病（ECC）管理中的临床疗效。进行了一项随机临床试验，比较了两种 ECC 管理策略：每隔四个月应用中性氟化物凝胶（NFG 组）和涂料（FV 组），为期一年。该样本由年龄在三到四岁之间的儿童组成，他们在公立日托中心就读。通过评估两个水平（牙釉质/牙本质受影响时的 d2 和牙本质受影响时的 d3）的数值（新 dmfs）来比较两组的 ECC 发生率：NFG 和 FV 组的龋齿发生率和增量。使用 Pearson 卡方检验、Fisher 精确检验、Kolmogorov-Smirnov 和 Mann-Whitney 检验比较 NFG 和 FV 组之间的龋齿发生率和增量（p<0.05）。共有 240 名儿童参与了这项研究，其中 213 名儿童（88.7%）随访 12 个月。GF 组的 ECC 发生率为 24.1%，FV 组为 21.0%（p=0.586）。NFG 组 d2mfs 的龋齿增量为 1.36（95%CI=0.83-1.89），FV 组为 1.33（95%CI=0.75-1.89）（p=0.756）。NFG 组 d3mfs 的龋齿增量为 1.60（95%CI=0.95-2.25），FV 组为 1.40（95%CI=0.75-2.04）（p=0.468）。在 12 个月的随访后，中性氟化物凝胶和氟化物涂料在 ECC 管理中的疗效相似。
