中国 1990 年至 2019 年的胰腺炎负担及相关危险因素：2019 年全球疾病负担研究的系统分析。

Burden of pancreatitis and associated risk factors in China, 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.

机构信息

Department of Gastroenterology, First Medical Center of Chinese PLA General Hospital and Chinese PLA Medical School, Beijing 100853, China.

Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Disease, Second Medical Center of Chinese PLA General Hospital and Chinese PLA Medical School, Beijing 100853, China.

出版信息

Chin Med J (Engl). 2022 Jun 5;135(11):1340-1347. doi: 10.1097/CM9.0000000000002164.

DOI:10.1097/CM9.0000000000002164

PMID:35830210

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9433084/

Abstract

BACKGROUND

Pancreatitis is a common disease of the digestive system. Acute pancreatitis is one of the most common reasons for gastrointestinal hospital admission, and chronic pancreatitis significantly reduces quality of life. However, national epidemiological data on pancreatitis in China are lacking. This study aimed to quantify the disease burden of pancreatitis in China from 1990 to 2019.

METHODS

This study was based on the Global Burden of Disease Study 2019 dataset. Age-standardized rates of incidence (ASIR), prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) were used to describe the disease burden of pancreatitis, and estimated annual percentage change (EAPC) was used to indicate the average change in age-standardized rates. We also described the trend of pancreatitis-related mortality and DALYs, which are attributable to alcohol use by age and sex.

RESULTS

From 1990 to 2019, the ASIR, ASPR, ASMR, and age-standardized DALYs of pancreatitis in China decreased by 10.90, 1.50, 0.49, and 15.54 per 100,000, respectively, with EAPCs of -1.35 (95% uncertainty interval [UI]: -1.67, -1.02) and -0.37 (95% UI: -0.43, -0.31), -2.01 (95% UI: -2.07, -1.94) and -2.32 (95% UI: -2.37, -2.28), respectively. Recently, the numbers of incident and prevalent cases have risen, with estimates of 380,018 (95% UI: 308,669-462,767) and 493,765 (95% UI: 416,705-578,675), respectively, in 2019. Among men, the disease burden of pancreatitis was more severe than among women, and with variances in the distribution among different age groups. Age-standardized DALYs caused by alcohol-related pancreatitis have gradually worsened in the past decade, accounting for 34.09% of the total in 2019.

CONCLUSIONS

The disease burden of pancreatitis in China has declined in the past 30 years, but the exacerbation of population aging poses a challenge to prevention and control of pancreatitis. Alcohol use has gradually become an important factor in the disease burden of pancreatitis in recent years.

摘要

背景

胰腺炎是一种常见的消化系统疾病。急性胰腺炎是胃肠道住院的最常见原因之一，而慢性胰腺炎则显著降低了生活质量。然而，中国关于胰腺炎的全国性流行病学数据却很缺乏。本研究旨在量化 1990 年至 2019 年中国胰腺炎的疾病负担。

方法

本研究基于 2019 年全球疾病负担研究数据集。发病率（ASIR）、患病率（ASPR）、死亡率（ASMR）和伤残调整生命年（DALYs）的年龄标准化率用于描述胰腺炎的疾病负担，年平均变化百分比（EAPC）用于表示年龄标准化率的平均变化。我们还描述了与酒精使用相关的胰腺炎死亡率和 DALY 的变化趋势，以及按年龄和性别划分的情况。

结果

1990 年至 2019 年，中国胰腺炎的 ASIR、ASPR、ASMR 和年龄标准化 DALYs 分别下降了 10.90、1.50、0.49 和 15.54/100000，EAPC 分别为-1.35（95%置信区间[95%UI]：-1.67，-1.02）和-0.37（95%UI：-0.43，-0.31）、-2.01（95%UI：-2.07，-1.94）和-2.32（95%UI：-2.37，-2.28）。最近，发病和患病例数有所增加，2019 年的估计值分别为 380018（95%UI：308669-462767）和 493765（95%UI：416705-578675）。男性的胰腺炎疾病负担比女性更严重，且在不同年龄组的分布上存在差异。与酒精相关的胰腺炎导致的年龄标准化 DALYs 在过去十年中逐渐恶化，在 2019 年占总负担的 34.09%。