Xiang Bingjie, Zhong Xiaoli, Li Fanglin, Zhong Yanjun, Li Jinxiu
Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.
Dig Dis Sci. 2025 Jul 24. doi: 10.1007/s10620-025-09247-w.
Pancreatitis is a significant global health concern, particularly among working-age adults, yet comprehensive evaluations are scarce.
Using Global Burden of Disease Study 2021 data, we assessed the prevalence, mortality, and disability-adjusted life years (DALYs) of pancreatitis in individuals aged 20-54 years across 204 countries from 1990 to 2021. Age-standardized rates (ASRs) and estimated annual percentage changes (EAPCs) were analyzed.
Globally, ASRs for prevalence, mortality, and DALYs declined from 1990 to 2021. The most pronounced decline occurred in prevalence (EAPC, - 1.1; 95% CI, - 1.2 to - 1.0), whereas mortality (EAPC, - 0.6; 95% CI, - 0.8 to - 0.5) and DALYs (EAPC, - 0.6; 95% CI, - 0.77 to - 0.5) showed only modest reductions. Regional disparities existed, with reductions in High-income Asia Pacific, East Asia, and Central Europe and rising trends in Eastern Europe and parts of Sub-Saharan Africa. In 2021, Eastern Europe had the highest prevalence (791.4 per 100,000), mortality (6.3 per 100,000) and DALYs (349.4 per 100,000) ASRs. At the national level, the Russian Federation reported the highest burden. Age-specific analyses revealed a peak in burden in middle adulthood, with males exhibiting higher rates. A nonlinear relationship with the Socio-Demographic Index (SDI) was observed, with burden peaking in middle-SDI regions. High alcohol consumption was a major risk factor, particularly in parts of Europe and Australasia.
Despite overall declines, limited reductions in mortality and DALYs indicate little improvement in prognosis. Pancreatitis remains a major global health issue, particularly in regions like Eastern Europe, underscoring the need for better prevention and management.
胰腺炎是一个重大的全球健康问题，在工作年龄成年人中尤为突出，但全面评估却很匮乏。
利用《2021年全球疾病负担研究》数据，我们评估了1990年至2021年期间204个国家20至54岁个体中胰腺炎的患病率、死亡率和伤残调整生命年（DALYs）。分析了年龄标准化率（ASRs）和估计年百分比变化（EAPCs）。
全球范围内，1990年至2021年期间，胰腺炎患病率、死亡率和伤残调整生命年的年龄标准化率均有所下降。患病率下降最为显著（EAPC，-1.1；95%CI，-1.2至-1.0），而死亡率（EAPC，-0.6；95%CI，-0.8至-0.5）和伤残调整生命年（EAPC，-0.6；95%CI，-0.77至-0.5）仅略有下降。存在区域差异，高收入亚太地区、东亚和中欧有所下降，而东欧和撒哈拉以南非洲部分地区呈上升趋势。2021年，东欧的患病率（每10万人791.4例）、死亡率（每10万人6.3例）和伤残调整生命年年龄标准化率（每10万人349.4例）最高。在国家层面，俄罗斯联邦报告的负担最重。按年龄分析显示，中年时期负担达到峰值，男性发病率更高。观察到与社会人口指数（SDI）呈非线性关系，负担在中等SDI地区达到峰值。高酒精消费是一个主要风险因素，尤其是在欧洲部分地区和澳大拉西亚。
尽管总体有所下降，但死亡率和伤残调整生命年的有限下降表明预后改善甚微。胰腺炎仍然是一个重大的全球健康问题，尤其是在东欧等地区，这凸显了加强预防和管理的必要性。
