对患有乳糜泻的成年患者十二指肠活检组织中的病毒核酸进行分析。
Analysis of viral nucleic acids in duodenal biopsies from adult patients with celiac disease.
作者信息
Calabretto Marianna, Di Carlo Daniele, Falasca Francesca, Mazzuti Laura, Meacci Arianna, Donato Giuseppe, Greco Nicoletta, Mezzatesta Laura, Morrone Anna, Turriziani Ombretta, Picarelli Antonio
机构信息
Department of Molecular Medicine, Sapienza University of Rome.
Istituto Pasteur Italia-Cenci Bolognetti Foundation, Rome.
出版信息
Eur J Gastroenterol Hepatol. 2022 Nov 1;34(11):1107-1110. doi: 10.1097/MEG.0000000000002404. Epub 2022 Jul 14.
OBJECTIVE
The purpose of this study was to investigate the presence of Adenovirus, Epstein-Barr virus (EBV), HHV-6 and cytomegalovirus (CMV) nucleic acids in the gastrointestinal biopsies from active CD patients.
METHODS
Gastrointestinal biopsies of 40 active CD patients and 40 non-CD patients were collected during the endoscopic investigation of gastrointestinal symptoms.
RESULTS
HHV-6B was found in 62.5% of CD patients and in 65% of non-CD individuals, whereas the prevalence of EBV-positive samples was 20 and 10%, respectively. Nucleic acids from HHV-6A, CMV and adenovirus were not detected in any group.
CONCLUSION
These data suggest that these viruses may not play a role in the pathogenesis of acute CD, but they do not exclude the possibility that viruses can act as a trigger for the onset of celiac disease.
目的
本研究旨在调查活动性克罗恩病（CD）患者胃肠道活检组织中腺病毒、爱泼斯坦-巴尔病毒（EBV）、人疱疹病毒6型（HHV-6）和巨细胞病毒（CMV）核酸的存在情况。
方法
在对胃肠道症状进行内镜检查期间，收集了40例活动性CD患者和40例非CD患者的胃肠道活检组织。
结果
62.5%的CD患者和65%的非CD个体中发现了HHV-6B，而EBV阳性样本的患病率分别为20%和10%。在任何组中均未检测到HHV-6A、CMV和腺病毒的核酸。
结论
这些数据表明，这些病毒可能在急性CD的发病机制中不起作用，但它们并不排除病毒可作为乳糜泻发病诱因的可能性。
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