MTRR 和 TNF-α 基因多态性与前牙开颌儿童口腔健康相关生活质量的关联证据。
Evidence of Association between MTRR and TNF-α Gene Polymorphisms and Oral Health-Related Quality of Life in Children with Anterior Open Bite.
机构信息
Ellen Cardoso Teixeira, DDS, MSc, Postgraduate Program in Dentistry of Niterói, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Bruno Moreira das Neves, DDS, MSc, Postgraduate Program in Dentistry of Nova Friburgo, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil.
出版信息
J Clin Pediatr Dent. 2022 May 1;46(3):249-258. doi: 10.17796/1053-4625-46.3.12.
UNLABELLED
Genetic polymorphisms could explain the inter-individual differences in the oral health-related quality of life (OHRQoL) of children with anterior open bite (AOB).
OBJECTIVE
To assess the impact of AOB on OHRQoL in children and to evaluate whether MTR (rs1805087), MTRR (rs1801394), TGFβ1 (rs1800469) and TNF-α (rs1799964, rs1799724 and rs1800629) genes are potential biomarkers for OHRQoL in children with AOB.
STUDY DESIGN
A cross-sectional study was performed with 173 children aged between 2-6 years. The Brazilian version of Early Childhood Oral Health Impact Scale (ECOHIS) was applied. Genetic polymorphisms were analyzed using real-time PCR. Mann-Whitney U-test and Chi-square were used.
RESULTS
The overall mean ECOHIS scores were 5.49 (SD= 5.72) and 3.45 (SD = 4.49) (p < 0.01) in the AOB and control groups, respectively. Children with the CC genotype of TNF-α (rs1799724) had a significantly higher psychological QoL level. The MTRR AA genotype group showed a lower QoL level in the child subscale (p = 0.006), function (p = 0.017), and psychological (p = 0.006) domains. There was no significant difference between OHRQoL and the genetic polymorphisms in MTR and TGFβ1.
CONCLUSIONS
Genetic polymorphisms in TNF-α and MTRR are associated with the impact on the OHRQoL in children with AOB.
未加标签
遗传多态性可能解释了有前牙开（AOB）的儿童口腔健康相关生活质量（OHRQoL）的个体间差异。
目的
评估 AOB 对儿童 OHRQoL 的影响，并评估 MTR(rs1805087)、MTRR(rs1801394)、TGFβ1(rs1800469)和 TNF-α(rs1799964、rs1799724 和 rs1800629)基因是否为 AOB 儿童 OHRQoL 的潜在生物标志物。
研究设计
对 173 名 2-6 岁的儿童进行了横断面研究。应用巴西版早期儿童口腔健康影响量表（ECOHIS）。使用实时 PCR 分析遗传多态性。使用 Mann-Whitney U 检验和卡方检验。
结果
AOB 和对照组的 ECOHIS 总分分别为 5.49(SD=5.72)和 3.45(SD=4.49)(p<0.01)。TNF-α(rs1799724)的 CC 基因型儿童的心理 QoL 水平显著较高。MTRR AA 基因型组在儿童子量表(p=0.006)、功能(p=0.017)和心理(p=0.006)领域的 QoL 水平较低。MTR 和 TGFβ1 的遗传多态性与 OHRQoL 之间无显著差异。
结论
TNF-α和 MTRR 的遗传多态性与 AOB 儿童 OHRQoL 的影响有关。
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