Marcus Z H, Lunenfeld B, Weissenberg R, Lewin L M
Gynecol Obstet Invest. 1987;23(1):54-9. doi: 10.1159/000298834.
Human seminal plasma from normal or patients with abnormal parameters of the ejaculates contains an inhibitory material that expresses potent in vitro inhibitory activity on PHA-M-induced blast transformation and NK activity. Using the test of inhibition of NK activity, the semen samples from individuals with higher concentrations of fructose had higher inhibitory activity. The results described herein suggest that inhibitory activity for blast transformation may be present in the prostatic fluid while the NK inhibition aspects are correlated with the vesicle-marker (fructose). Inhibition of the immune responses by human seminal plasma of the effector functions indicates the interesting implication that soluble factors may indirectly protect against or promote human autoimmune infertility disease.
来自正常或射精参数异常患者的人类精浆含有一种抑制物质，该物质对PHA-M诱导的淋巴细胞转化和自然杀伤（NK）活性具有强大的体外抑制活性。通过NK活性抑制试验发现，果糖浓度较高个体的精液样本具有更高的抑制活性。本文所述结果表明，对淋巴细胞转化的抑制活性可能存在于前列腺液中，而NK抑制方面则与精囊标志物（果糖）相关。人类精浆对效应功能的免疫反应抑制表明了一个有趣的现象，即可溶性因子可能间接预防或促发人类自身免疫性不育症。
