Stopping prereferral rectal artesunate - a grave error.
作者信息
Watson James A, Warsame Marian, Peto Thomas J, Onyamboko Marie, Fanello Caterina, Dondorp Arjen M, White Nicholas
机构信息
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
出版信息
BMJ Glob Health. 2022 Jul;7(7). doi: 10.1136/bmjgh-2022-010006.
Abstract
摘要
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Stopping prereferral rectal artesunate - a grave error.停止转诊前直肠用青蒿琥酯——一个严重错误。
BMJ Glob Health. 2022 Jul;7(7). doi: 10.1136/bmjgh-2022-010006.
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Compliance With Referral Advice After Treatment With Prereferral Rectal Artesunate: A Study in 3 Sub-Saharan African Countries.转诊前直肠青蒿琥酯治疗后对转诊建议的依从性：撒哈拉以南非洲3个国家的一项研究。
Clin Infect Dis. 2016 Dec 15;63(suppl 5):S283-S289. doi: 10.1093/cid/ciw627.
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Pre-referral Rectal Artesunate Treatment by Community-Based Treatment Providers in Ghana, Guinea-Bissau, Tanzania, and Uganda (Study 18): A Cluster-Randomized Trial.加纳、几内亚比绍、坦桑尼亚和乌干达的社区治疗提供者进行的转诊前直肠青蒿琥酯治疗（研究18）：一项整群随机试验。
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Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria and Uganda.刚果民主共和国、尼日利亚和乌干达疑似严重疟疾儿童的转诊前直肠青蒿琥酯和转诊完成情况。
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Rectal artesunate suppositories for the pre-referral treatment of suspected severe malaria.直肠用青蒿琥酯栓剂治疗疑似重症疟疾的转诊前治疗。
PLoS Med. 2023 Nov 9;20(11):e1004312. doi: 10.1371/journal.pmed.1004312. eCollection 2023 Nov.
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Rectal artesunate as pre-referral treatment for severe malaria in sub-Saharan Africa: still a long way to go.在撒哈拉以南非洲地区，直肠用青蒿琥酯作为重症疟疾转诊前的治疗方法：仍有很长的路要走。
Lancet Glob Health. 2023 Feb;11(2):e181-e182. doi: 10.1016/S2214-109X(22)00524-1. Epub 2022 Dec 21.
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The CARAMAL study could not assess the effectiveness of rectal artesunate in treating suspected severe malaria.卡拉玛尔研究未能评估直肠青蒿琥酯治疗疑似重症疟疾的效果。
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Adherence to the referral advice after introduction of rectal artesunate for pre-referral treatment of severe malaria at the community level: a noninferiority trial in the Democratic Republic of the Congo.在社区层面引入直肠青蒿琥酯作为疟疾前转诊治疗后，对转诊建议的坚持情况：刚果民主共和国的一项非劣效性试验。
Malar J. 2019 Dec 21;18(1):438. doi: 10.1186/s12936-019-3074-6.
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Pre-referral rectal artesunate: no cure for unhealthy systems.转诊前直肠青蒿琥酯：无法治愈不健康的系统。
Lancet Infect Dis. 2023 Jun;23(6):e213-e217. doi: 10.1016/S1473-3099(22)00762-9. Epub 2022 Dec 19.
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The wrongful indictment of pre-referral rectal artesunate further delays the roll-out of this lifesaving drug.错误起诉转诊前直肠青蒿琥酯进一步延误了这种救命药物的推广。
Lancet Infect Dis. 2023 Jun;23(6):e208-e212. doi: 10.1016/S1473-3099(22)00765-4. Epub 2022 Dec 19.
引用本文的文献
1
Rectal artesunate suppositories for the pre-referral treatment of suspected severe malaria.直肠用青蒿琥酯栓剂治疗疑似重症疟疾的转诊前治疗。
PLoS Med. 2023 Nov 9;20(11):e1004312. doi: 10.1371/journal.pmed.1004312. eCollection 2023 Nov.
2
Rectal artesunate for severe malaria, implementation research, Zambia.直肠青蒿琥酯治疗重症疟疾的实施研究，赞比亚。
Bull World Health Organ. 2023 Jun 1;101(6):371-380A. doi: 10.2471/BLT.22.289181. Epub 2023 Apr 17.
3
The CARAMAL study could not assess the effectiveness of rectal artesunate in treating suspected severe malaria.卡拉玛尔研究未能评估直肠青蒿琥酯治疗疑似重症疟疾的效果。
BMC Med. 2023 Mar 30;21(1):118. doi: 10.1186/s12916-023-02776-z.
4
WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria.世界卫生组织应该加快而不是拖延直肠青蒿琥酯在转诊前治疗重症疟疾中的应用。
Trans R Soc Trop Med Hyg. 2023 Jul 4;117(7):536-538. doi: 10.1093/trstmh/trad002.
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The prognostic and diagnostic value of intraleukocytic malaria pigment in patients with severe falciparum malaria.白细胞内疟色素对重症恶性疟患者的预后和诊断价值。
Nat Commun. 2022 Nov 12;13(1):6882. doi: 10.1038/s41467-022-34678-8.
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Severe malaria.严重疟疾。
Malar J. 2022 Oct 6;21(1):284. doi: 10.1186/s12936-022-04301-8.
本文引用的文献
1
Community access to rectal artesunate for malaria (CARAMAL): A large-scale observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda.社区获取青蒿琥酯直肠给药治疗疟疾项目（CARAMAL）：在刚果民主共和国、尼日利亚和乌干达开展的一项大规模观察性实施研究。
PLOS Glob Public Health. 2022 Sep 6;2(9):e0000464. doi: 10.1371/journal.pgph.0000464. eCollection 2022.
2
Improving the diagnosis of severe malaria in African children using platelet counts and plasma HRP2 concentrations.利用血小板计数和血浆 HRP2 浓度提高对非洲儿童严重疟疾的诊断。
Sci Transl Med. 2022 Jul 20;14(654):eabn5040. doi: 10.1126/scitranslmed.abn5040.
3
Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria and Uganda.刚果民主共和国、尼日利亚和乌干达疑似严重疟疾儿童的转诊前直肠青蒿琥酯和转诊完成情况。
BMJ Glob Health. 2022 May;7(5). doi: 10.1136/bmjgh-2021-008346.
4
Pharmacokinetic Study of Rectal Artesunate in Children with Severe Malaria in Africa.非洲重症疟疾儿童直肠用青蒿琥酯的药代动力学研究。
Antimicrob Agents Chemother. 2021 Mar 18;65(4). doi: 10.1128/AAC.02223-20.
5
The Magic of Randomization versus the Myth of Real-World Evidence.随机化的魔力与真实世界证据的神话
N Engl J Med. 2020 Feb 13;382(7):674-678. doi: 10.1056/NEJMsb1901642.
6
Adherence to the referral advice after introduction of rectal artesunate for pre-referral treatment of severe malaria at the community level: a noninferiority trial in the Democratic Republic of the Congo.在社区层面引入直肠青蒿琥酯作为疟疾前转诊治疗后，对转诊建议的坚持情况：刚果民主共和国的一项非劣效性试验。
Malar J. 2019 Dec 21;18(1):438. doi: 10.1186/s12936-019-3074-6.
7
Pre-referral Rectal Artesunate Treatment by Community-Based Treatment Providers in Ghana, Guinea-Bissau, Tanzania, and Uganda (Study 18): A Cluster-Randomized Trial.加纳、几内亚比绍、坦桑尼亚和乌干达的社区治疗提供者进行的转诊前直肠青蒿琥酯治疗（研究18）：一项整群随机试验。
Clin Infect Dis. 2016 Dec 15;63(suppl 5):S312-S321. doi: 10.1093/cid/ciw631.
8
Compliance With Referral Advice After Treatment With Prereferral Rectal Artesunate: A Study in 3 Sub-Saharan African Countries.转诊前直肠青蒿琥酯治疗后对转诊建议的依从性：撒哈拉以南非洲3个国家的一项研究。
Clin Infect Dis. 2016 Dec 15;63(suppl 5):S283-S289. doi: 10.1093/cid/ciw627.
9
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial.青蒿琥酯与奎宁治疗非洲儿童重症恶性疟的疗效比较（AQUAMAT）：一项开放标签、随机临床试验。
Lancet. 2010 Nov 13;376(9753):1647-57. doi: 10.1016/S0140-6736(10)61924-1. Epub 2010 Nov 7.
10
Pre-referral rectal artesunate to prevent death and disability in severe malaria: a placebo-controlled trial.转诊前使用青蒿琥酯预防重症疟疾死亡和残疾：一项安慰剂对照试验。
Lancet. 2009 Feb 14;373(9663):557-66. doi: 10.1016/S0140-6736(08)61734-1. Epub 2008 Dec 6.
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