Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, 325-Cidade Universitária, Rio de Janeiro, RJ, CEP 21941-971, Brazil.
Department of Corporate Management, ESIC Business and Marketing School, Pozuelo, Madrid, Spain.
Eur Arch Paediatr Dent. 2022 Dec;23(6):869-883. doi: 10.1007/s40368-022-00726-6. Epub 2022 Jul 13.
Chemical-mechanical caries removal (CMCR) products are in constant evolution and were recommended during the COVID-19 pandemic as substitutes for conventional caries removal.
Characterize the worldwide scientific literature about CMCR products, over the years, by means of a critical review.
Electronic search was performed on Medline/PubMed, Scopus, Web of Science, Cochrane Library, Lilacs, and Embase up to November 2020. Year, journal, country of authors, and type of study were the data extracted from the retrieved studies. Additional data of the clinical studies and systematic reviews were investigated.
2221 records were identified, 397 selected. 2011-2020 period concentrates higher number of publications (n = 169), in the Journal of Dental Research (n = 51), developed in Brazil (n = 45) and India (n = 44). Most studies were in vitro (n = 211) and clinical trials (n = 101). Carisolv™ (n = 48) and Papacarie Duo Gel™ (n = 33) were the most used products, prescript in isolated usage (n = 101), and compared with drills (n = 77). CMCR were more studied in primary teeth (n = 78), receiving glass ionomer cement (GIC) (n = 51) as restorative material. The most evaluated outcomes were time spent (n = 48) and pain (n = 41). Clinical application of CMCR takes more time than other techniques, but can also reduce patient anxiety, pain, and need for anesthesia.
In vitro and clinical studies with CMCR products have been increasing, mostly carried out in developing countries, evaluating Carisolv™ and Papacarie Duo Gel™. Clinical studies tend to evaluate the time spent and pain compared to drills for removing caries in primary teeth, posteriorly restored with GIC. CMCR clinical application reduces anxiety, pain, and need for anesthesia, despite increase treatments' time.
化学机械去龋（CMCR）产品不断发展，在 COVID-19 大流行期间被推荐作为传统去龋的替代品。
通过文献回顾分析，描述多年来全球范围内有关 CMCR 产品的科学文献。
检索 Medline/PubMed、Scopus、Web of Science、Cochrane 图书馆、Lilacs 和 Embase 数据库，检索时限截至 2020 年 11 月。从检索到的研究中提取数据，包括年份、期刊、作者所在国家和研究类型。对临床研究和系统评价的附加数据进行了调查。
共识别出 2221 条记录，选择了 397 条记录。2011-2020 年期间发表的文献数量较多（n=169），主要发表在《牙研究杂志》（n=51），作者来自巴西（n=45）和印度（n=44）。大多数研究为体外研究（n=211）和临床试验（n=101）。Carisolv（n=48）和 Papacarie Duo Gel（n=33）是使用最多的产品，单独使用（n=101），与牙钻（n=77）比较。CMCR 在乳牙（n=78）中研究较多，作为修复材料，玻璃离子水门汀（GIC）（n=51）。评价最多的结局是时间（n=48）和疼痛（n=41）。CMCR 的临床应用比其他技术花费的时间更多，但也可以减少患者的焦虑、疼痛和麻醉需求。
体外和临床研究中，CMCR 产品的应用不断增加，主要在发展中国家进行，评估 Carisolv 和 Papacarie Duo Gel。临床研究倾向于评价时间和疼痛，与牙钻比较，用于去除乳牙的龋坏，随后用 GIC 修复。CMCR 的临床应用减少了焦虑、疼痛和麻醉需求，尽管治疗时间增加。
